Toward Developing a Preventive MERS-CoV Vaccine-Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14-15, 2015.
Toward Developing a Preventive MERS-CoV Vaccine-Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14-15, 2015.
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DOI：
10.3201/eid2208.160229
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发表时间：
2016-08
影响因子：
11.8
通讯作者：
MERS-CoV Vaccine Working Group
中科院分区：
文献类型：
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作者：
Excler JL;Delvecchio CJ;Wiley RE;Williams M;Yoon IK;Modjarrad K;Boujelal M;Moorthy VS;Hersi AS;Kim JH;MERS-CoV Vaccine Working Group
中东呼吸综合征（MERS）仍然是一个严重的国际公共卫生威胁。为了加速开发MERS冠状病毒（MERS-CoV）的对策，世界各地的资助机构、非政府组织和研究人员于2015年11月14日至15日聚集在沙特阿拉伯的利雅得，讨论疫苗开发的挑战。会议由沙特卫生部牵头，韩国国际疫苗研究所协办。加快预防性疫苗的开发需要更好地了解MERS在人类和动物中的流行病学、传播和发病机制。在评价和开发预防性和治疗性候选疫苗时，应考虑啮齿动物和非人灵长类动物模型的组合。应考虑用单峰骆驼开发兽用疫苗。讨论了几种靶向MERS CoV刺突蛋白的疫苗技术平台。迫切需要建立机制，以最大限度地增加投资，提供可靠的数据，并影响公共卫生。
Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.