EFFECTS OF FIBRIN AND FIBRINOGEN-DEGRADATION PRODUCTS ON THE GROWTH OF RABBIT AORTIC SMOOTH-MUSCLE CELLS IN CULTURE
EFFECTS OF FIBRIN AND FIBRINOGEN-DEGRADATION PRODUCTS ON THE GROWTH OF RABBIT AORTIC SMOOTH-MUSCLE CELLS IN CULTURE
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DOI：
10.1016/0021-9150(82)90111-3
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发表时间：
1982-01-01
期刊：
影响因子：
5.3
通讯作者：
TANAKA, K
中科院分区：
文献类型：
--
作者：
ISHIDA, T;TANAKA, K
纤维素含有促进间充质细胞生长的因子，可能与组织修复有关。本实验观察了纤维蛋白及其降解产物（FDP）对培养的兔动脉平滑肌细胞（SMC）生长的影响。去纤溶酶原的纤维蛋白酶在48 h内促进SMC的增殖。富含纤溶酶原的纤维素在24 h内刺激SMC增殖，48 h后抑制SMC增殖。FDP（片段D和E）抑制SMC增殖。家兔动脉平滑肌细胞具有纤溶酶原激活物活性。凝血酶和尿激酶对SMC的生长无促进作用。显然，SMC的增殖受到纤维蛋白的刺激，随后受到FDP的抑制，FDP是由SMC的纤维蛋白溶解活性产生的。动脉壁纤维蛋白的代谢可能在SMC增殖的调节中起重要作用，凝血-纤溶系统可能在动脉粥样硬化的形成中起重要作用。
Fibrin contains a factor which promotes growth of the mesenchymal cells and may be related to tissue repair. Effects of fibrin and fibrinogen degradation products (FDP) on the growth of smooth muscle cells (SMC) of rabbit aortas in culture were investigated in relation to atherogenesis. Fibrin free from plasminogen enhanced the proliferation of SMC during the experimental period of 48 h. Fibrin rich in plasminogen also stimulated the proliferation of SMC within 24 h but inhibited it after 48 h. FDP (fragments D and E) inhibited the proliferation of SMC. SMC of rabbit aortas demonstrated plasminogen activator activity. Thrombin and urokinase exhibited no promoting effects on the growth of SMC. Apparently, the proliferation of SMC is stimulated by fibrin and later inhibited by FDP, as produced by the fibrinolytic activity of SMC. The metabolism of fibrin in the arterial wall may be of importance in the regulation of SMC proliferation and the coagulation-fibrinolysis system may play a significant role in atherogenesis.