Aqueous humor and serum IgE antibody in experimental ocular Onchocerca infection of guinea pigs.
Aqueous humor and serum IgE antibody in experimental ocular Onchocerca infection of guinea pigs.
复制标题
豚鼠实验性眼盘尾丝虫感染中的房水和血清 IgE 抗体。
DOI：
10.1159/000265237
复制
发表时间：
1983
影响因子：
2.1
通讯作者：
Soulsby,EJ
中科院分区：
文献类型：
--
作者：
Donnelly,JJ;Rockey,JH;Bianco,AE;Soulsby,EJ
近交系2号豚鼠皮下或皮内注射新鲜或冻存的细小丝虫活虫，然后攻击角膜内感染微丝虫，可产生血清和水液中的IgE抗体，并引起明显的角膜炎症。单独给予全身感染或眼内感染不足以引起IgE抗体或眼部炎症。当从系统感染的供者向正常的同基因受者静脉转移汇集的脾细胞悬液取代全身感染的病程时，细胞转移受者随后的角膜内感染微丝虫产生了血清和水样的IgE抗体。在角膜内激发后给受感染的动物注射柠檬酸二乙胺，可导致血清IgE抗体升高和角膜炎症增加。
Infection of inbred Strain 2 guinea pigs by subcutaneous or intradermal injection of fresh or cryopreserved livingOnchocerca lienalismicrofilariae, followed by a challenge intracorneal infection of microfilariae, resulted in serum and aqueous IgE antibody and in significant corneal inflammation. Systemic or intraocular infections given separately were not sufficient to elicit IgE antibody or ocular inflammation. When intravenous transfer of pooled spleen cell suspensions from systemically infected donors to normal syngeneic recipients was substituted for the course of systemic infections, a subsequent intracorneal challenge of cell transfer recipients with microfilariae produced serum and aqueous IgE antibody. Administration of diethylcarbamazine citrate to infected animals following the intracorneal challenge resulted in increased serum IgE antibody and in increased corneal inflammation.