Reductions in heroin use are not associated with increases in other drug use: 2-year findings from the Australian Treatment Outcome Study
Reductions in heroin use are not associated with increases in other drug use: 2-year findings from the Australian Treatment Outcome Study
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DOI：
10.1016/j.drugalcdep.2006.03.004
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发表时间：
2006-09-15
影响因子：
4.2
通讯作者：
Teesson, Maree
中科院分区：
文献类型：
--
作者：
Darke, Shane;Williamson, Anna;Teesson, Maree
目的：确定在24个月期间，海洛因使用频率的减少是否与其他药物使用的减少有关。设计：纵向队列，随访3、12和24个月。参与者：澳大利亚治疗结果研究招募了615名海洛因使用者。环境：澳大利亚新南威尔士州。结果：报告每周使用海洛因的比例在3、12和24个月时显著下降。海洛因使用的减少与住院康复（RR）和维持治疗（MT）的时间延长有关。在随访期间，注意到其他阿片类药物、可卡因、安非他明、大麻和苯二氮卓类药物的使用频率较低，酒精的使用保持稳定。在随访过程中，海洛因使用频率较低与其他阿片类药物、可卡因、安非他明和苯二氮卓类药物使用频率较低相关。酒精和大麻的使用与海洛因的使用无关。更长时间的RR与所有其他药物类别的使用减少有关，MT与其他阿片类药物和酒精使用减少有关。结论：在这组寻求治疗者中，没有证据表明在海洛因使用减少的情况下存在药物替代。有人担心寻求治疗的人成功减少海洛因的使用会导致其他药物的使用增加，这种担心似乎是没有根据的。2006爱思唯尔爱尔兰有限公司版权所有。
Aims: To determine whether reductions in frequency of heroin use were associated with reductions in the use of other drugs over a 24-month period.Design: Longitudinal cohort, with follow-up at 3, 12 and 24 months.Participants: Six hundred and fifteen heroin users recruited for the Australian Treatment Outcome Study.Setting: New South Wales, Australia.Findings: The proportion reporting weekly heroin use declined significantly at 3, 12 and 24 months. Reductions in heroin use were associated with longer periods in both residential rehabilitation (RR) and maintenance treatment (MT). Less frequent use of other opioids, cocaine, amphetamine, cannabis and benzodiazepines were noted over follow-up, with alcohol use remaining stable. Across follow-up, lower frequency heroin use was associated with reduced likelihood of frequent use of other opioids, cocaine, amphetamine and benzodiazepines. Alcohol and cannabis use were unrelated to heroin use. Longer periods spent in RR were associated with declines in the use of all other drug classes, with MT associated with declines in other opioid and alcohol use.Conclusions: There was no evidence for drug substitution in the face of reduced heroin use in this cohort of treatment seekers. The fear that a successful reduction in heroin use amongst treatment seekers will precipitate an increase in the use of other drugs appears ill-founded. (c) 2006 Elsevier Ireland Ltd. All rights reserved.