GH SECRETION STATUS IN MYOTONIC-DYSTROPHY
GH SECRETION STATUS IN MYOTONIC-DYSTROPHY
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DOI：
10.1016/0306-4530(93)90003-4
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发表时间：
1993-01-01
影响因子：
3.7
通讯作者：
SOLER, J
中科院分区：
文献类型：
--
作者：
GOMEZSAEZ, JM;FERNANDEZREAL, JM;SOLER, J
强直性肌营养不良症（MD）常伴有内分泌改变和生长激素（GH）分泌异常。为评价MD患者的GH分泌状况，研究了100 μ g生长激素释放激素（GHRH）加或不加吡啶斯的明预处理对MD患者GH的反应及其与胰岛素诱导低血糖的关系，并与正常对照组进行比较。正常人血浆GH对GHRH的平均峰值反应为27.8 ± 19.2 mug/l，MD患者为11.4 ± 8.7 mug/l。7例患者中有5例在胰岛素诱导的低血糖后GH达到平均峰值12.6 +/- 4.2 mug/l，而GHRH后为5 +/- 2.8 mug/l。相反，在两名患者中，GHRH后GH达到峰值16.1和32 mug/l，低血糖后分别仅为2.5和5.3 mug/l。在9名患者中，用吡啶斯的明预处理增强了GHRH诱导的GH释放，峰值为17.6 +/-12.5 mug/l，而单独使用GHRH后为10.05 +/-6.7 mug/l;所有患者的IGF-I水平均正常。
Frequent endocrine alterations and abnormal growth hormone (GH) secretion have been reported in myotonic dystrophy (MD). To evaluate GH secretion status in MD, GH response to 100 mug of growth hormone releasing hormone (GHRH) with or without pyridostigmine pretreatment and its relation with insulin-induced hypoglycemia was investigated in MD patients and compared with normal controls. The mean peak plasma GH response to GHRH was 27.8 +/- 19.2 mug/l normal subjects and 11.4 +/- 8.7 mug/l in MD patients. In five of seven patients GH reached a mean peak of 12.6 +/- 4.2 mug/l after insulin-induced hypoglycemia, compared with 5 +/- 2.8 mug/l after GHRH. Conversely, in two patients GH reached a peak of 16.1 and 32 mug/l after GHRH, and only 2.5 and 5.3, respectively, after hypoglycemia. Pretreatment with pyridostigmine in nine patients tested potentiated GHRH-induced GH release with a peak of 17.6 +/- 12,5 mug/l, compared with 10.05 +/-6.7 mug/l after GHRH alone; IGF-I levels were normal in all patients.