Rod ERGs in retinitis pigmentosa and cone-rod degeneration.
Rod ERGs in retinitis pigmentosa and cone-rod degeneration.
复制标题
视网膜色素变性和视锥杆变性中的杆 ERG。
DOI：
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发表时间：
1987
影响因子：
4.4
通讯作者：
G. Fish
中科院分区：
文献类型：
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作者：
D. Birch;G. Fish
通过确定 15 名正常受试者、25 名视杆细胞-视锥细胞变性患者和 10 名视锥细胞-视杆细胞变性患者的最佳拟合 Naka-Rushton 函数参数，分析视杆细胞振幅与视网膜照度的函数关系。通过确定记录视网膜照度的最佳线性拟合来分析杆状 b 波隐式时间。标准 b 波隐式时间和半最大振幅响应 (log k) 所需的视网膜照度是视杆细胞敏感性的高度相关指数。在所有年龄的锥杆变性患者中，这两项测量值均正常或接近正常，但在锥杆变性患者中显着升高。这些结果表明，这两种形式的遗传性视网膜变性中视杆变性的潜在机制根本不同。
Rod amplitudes as a function of retinal illuminance were analyzed by determining the parameters of the best fit Naka-Rushton function for 15 normal subjects, 25 patients with rod-cone degeneration, and 10 patients with cone-rod degeneration. Rod b-wave implicit times were analyzed by determining the best linear fit to log retinal illuminance. Retinal illuminances necessary for a criterion b-wave implicit time and for a half-maximum amplitude response (log k) were highly correlated indices of rod sensitivity. Both measures were normal or near normal in patients of all ages with cone-rod degeneration, but significantly elevated in patients with rod-cone degeneration. These results suggest that the underlying mechanisms of rod degeneration are fundamentally different in these two forms of hereditary retinal degeneration.