Changes in the cell population of the pregnant rodent uterus in relation to the differentiation of granulated metrial gland cells.
Changes in the cell population of the pregnant rodent uterus in relation to the differentiation of granulated metrial gland cells.
复制标题
怀孕啮齿动物子宫细胞群的变化与粒状子宫腺细胞的分化有关。
作者：
I. Stewart;S. Peel
为了研究粒状子宫腺细胞的起源，对小鼠基底蜕膜发育过程中细胞群的变化进行了延时放射自显影研究。粒状子宫腺细胞最初只占细胞的不到 1%，但在研究期间，它们的数量增加到占细胞的 14%。研究期间，未标记的淋巴细胞样细胞和粒状子宫腺前体细胞的比例显着下降。在妊娠第 4 1/2 天单次注射氚化胸苷后一小时，标记细胞（粒状细胞）的比例与总细胞（粒状细胞）的比例没有显着差异。然而，注射胸苷后84小时，标记细胞中粒状细胞的比例显着低于总细胞中粒状细胞的比例。对小鼠和大鼠发育中的心房腺的研究也得到了类似的结果。考虑了与粒状子宫腺细胞的宫外起源相关的结果的重要性。
A time-lapse autoradiographic study has been made of changes in the cell population of the decidua basalis during its development in the mouse, in order to investigate the origin of granulated metrial gland cells. Granulated metrial gland cells initially formed less than 1% of the cells but during the period of study they increased in number to form 14% of the cells. The proportion of unlabelled lymphocyte-like cells and granulated metrial gland precursor cells fell significantly during the period of study. One hour after a single injection of tritiated thymidine on day 4 1/2 of pregnancy the proportion of labelled cells which were granulated cells was not significantly different from the proportion of total cells which were granulated cells. However, 84 hours after the injection of thymidine the proportion of labelled cells which were granulated cells was significantly lower than the proportion of total cells which were granulated cells. Similar results were obtained from studies of the developing metrial gland of the mouse and rat. The significance of the results in relationship to an extrauterine origin for granulated metrial gland cells is considered.