PYRUVIC ACID, A UNIQUE COMPONENT OF AN EXOCELLULAR BACTERIAL POLYSACCHARIDE
PYRUVIC ACID, A UNIQUE COMPONENT OF AN EXOCELLULAR BACTERIAL POLYSACCHARIDE
复制标题
DOI：
10.1038/194478a0
复制
发表时间：
1962-01-01
期刊：
影响因子：
64.8
通讯作者：
ORENTAS, DG
中科院分区：
文献类型：
--
作者：
SLONEKER, JH;ORENTAS, DG
丙酮酸是一种广泛分布于自然界的代谢中间体，是许多生物来源化合物的构建单元。例如，在唾液酸（一种与动物粘蛋白相关的碳水化合物）的生物合成中，通过羟醛型缩合反应，将唾液酸与N-乙酰甘露糖胺酶促结合1，2。胞壁酸--细菌细胞壁的碳水化合物成分--被认为是由丙酮酸（磷酸烯醇丙酮酸）与N-乙酰基葡萄糖胺缩合产生的3。此外，已分离并鉴定了海藻酸作为商业红色海藻多糖的组分。结构研究表明，每51个己糖单元存在一个酸残基4，5。
PYRUVIC acid, a compound widely distributed in Nature as a metabolic intermediate, is a building unit for many compounds of biological origin. For example, in the biosynthesis of sialic acid—a carbohydrate associated with mucoproteins in animals—pyruvic acid is combined enzymatically withN-acetyl mannosamine by an aldol-type condensation1,2. Muramic acid—a carbohydrate constituent of bacterial cell walls—is thought to arise from a condensation of pyruvic acid, as phosphoenol pyruvate, withN-acetyl glucosamine3. Also, pyruvic acid has been isolated and identified as a component of a commercial red seaweed polysaccharide. Structural studies indicate the presence of one acid residue for each 51 hexose units4,5.