Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
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DOI：
10.1007/s00464-011-1793-z
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发表时间：
2011-12-01
影响因子：
3.1
通讯作者：
Saluja, Satish
中科院分区：
文献类型：
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作者：
Agarwal, Krishna Adit;Tripathi, C. D.;Saluja, Satish
腹腔镜胆囊切除术（LC）的患者报告结局（PRO）更好取决于PRO，如术后疼痛和疲劳。这些PRO是恢复和恢复正常活动的指标。姜黄素（姜黄）在印度用于治疗创伤性疼痛和疲劳，因为它具有抗炎/抗氧化和组织调节/愈合特性。我们研究了姜黄素对LC患者疼痛和术后疲劳的影响。从2009年7月至9月，连续50名日间护理LC候选人参加了一项前瞻性，双盲随机安慰剂对照研究。遵循统一的全身麻醉和镇痛方案。出院时处方姜黄素/安慰剂和补救镇痛药。告知患者根据100分视觉模拟疼痛量表（VAS）和10分间隔评定疲劳量表（IRS）记录疼痛/疲劳/不良事件日记。患者在第3天（D3）、第1周（W1）、第2周（W2）和第3周（W3）进行随访。研究结束时揭盲，研究组（n = 25）和对照组（n = 25）的人口统计学特征、合并症和胆囊病理学特征相似。无不良手术结局、不良PRO或退出。两组在D3时的疼痛和疲劳评分相似。在W1和W2时，研究组的平均疼痛评分显著较低（p值0.000），即，15 +/-A5.204对比对照中的30 +/-A13。研究组在W1、W2和W3时的疲劳评分显著较低（p值0.000），即，2.16+/- A分别为1.748、1和0，而对照组为5.16 +/- A 1.375、4.20 +/- A 1.633和1。所有患者在W3时均无疼痛。研究组中止痛片的使用显著较低（p值0.000），即，6.96+/-A1.837对比对照组39.32 +/-A16.509姜黄素改善LC术后疼痛和疲劳相关PRO。
Better patient-reported outcomes (PROs) of laparoscopic cholecystectomy (LC) are premised upon PROs such as postoperative pain and fatigue. These PROs are indices of convalescence and return to normal activity. Curcumin (turmeric) is used in India for traumatic pain and fatigue for its anti-inflammatory/antioxidant and tissue modulation/healing properties. We studied the effect of curcumin on pain and postoperative fatigue in patients of LC.From July to September 2009, 50 consecutive day-care LC candidates were enrolled for a prospective, double-blind randomized placebo-controlled study. A uniform general anesthesia and analgesia protocol was followed. Curcumin/placebo and rescue analgesic were prescribed at discharge. Patients were told to maintain pain/fatigue/adverse event diaries based upon 100-point visual analog pain scale (VAS) and 10-point interval rating fatigue scale (IRS). Patients were followed up at third day (D3), first week (W1), second week (W2), and third week (W3). The blind labels were opened at the end of study.Demographic characteristics, comorbidity, and gallbladder pathology profiles were comparable in the study (n = 25) and control groups (n = 25). There was no adverse surgical outcome, adverse PRO or withdrawal. Pain and fatigue scores at D3 were similar in the two groups. At W1 and W2, the study group showed significantly lower (p value 0.000) mean pain scores, i.e., 15 +/- A 5.204 versus 30 +/- A 13 in controls. Fatigue scores at W1, W2, and W3 were significantly lower (p value 0.000) in the study group, i.e., 2.16 +/- A 1.748, 1, and 0, respectively, versus 5.16 +/- A 1.375, 4.20 +/- A 1.633, and 1 in controls. All patients were pain free at W3. Analgesic tablet usage was significantly lower (p value 0.000) in the study group, i.e., 6.96 +/- A 1.837 versus 39.32 +/- A 16.509 in controls.Turmeric (curcumin) improves postoperative pain- and fatigue-related PROs following LC.