Validity of a new automated software program for visceral adipose tissue estimation
Validity of a new automated software program for visceral adipose tissue estimation
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DOI：
10.1038/sj.ijo.0803409
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发表时间：
2007-02-01
影响因子：
4.9
通讯作者：
Towne, B.
中科院分区：
文献类型：
--
作者：
Demerath, E. W.;Ritter, K. J.;Towne, B.
考虑到分析生物医学图像以量化脂肪组织体积的大量时间和研究成本，自动化图像分析方法是非常可取的。河马脂肪（TM）是一个新的软件程序，旨在自动量化脂肪组织区域的磁共振图像，无需用户输入。河马脂肪（TM）尚未独立验证常用的图像分析软件程序。目的：我们的目的是比较使用新的Hippo Fat （TM）软件对VAT（内脏脂肪组织）和SAT（皮下脂肪组织）的估计与广泛使用的，经过验证的计算机辅助手动方法（切片- o -matic版本4.2,Tomovision, Montreal， CA， USA）的估计，以评估其在大规模研究中的潜在效用。方法：采用Siemens Magnetom Vision 1.5 t全身扫描仪和t1加权快旋回波脉冲序列采集40例年龄18-77岁、平均体重指数29 kg/m(2)（范围19-43 kg/m(2)）的健康成人（男性20例）腹部多张连续轴向图像。结果：Hippo Fat （TM）提供的VAT和SAT估计值与使用slice-O-matic （R-2 > 0.9）的估计值高度相关。与切片- o -matic相比，使用河马脂肪（TM）的平均增值税降低了9.4%，平均SAT提高了3.7%；肥胖程度越高的个体对SAT的高估程度越高。增值税的个人水平差异也很大；Hippo Fat （TM）给出的增值税估计值比使用slice-O-matic的同一个人的估计值少1184厘米(3)到多566厘米(3)不等。结论：Hippo Fat （TM）提供了一种快速量化总VAT的方法，尽管该方法不能在组（平均）或个体水平上提供与slice-O-matic可互换的估计。
Introduction: Given the considerable time and research cost of analyzing biomedical images to quantify adipose tissue volumes, automated image analysis methods are highly desirable. Hippo Fat (TM) is a new software program designed to automatically quantify adipose tissue areas from magnetic resonance images without user inputs. Hippo Fat (TM) has yet to be independently validated against commonly used image analysis software programs.Objective: Our aim was to compare estimates of VAT (visceral adipose tissue) and SAT (subcutaneous adipose tissue) using the new Hippo Fat (TM) software against those from a widely used, validated, computer-assisted manual method (slice-O-matic version 4.2, Tomovision, Montreal, CA, USA) to assess its potential utility for large-scale studies.Methods: A Siemens Magnetom Vision 1.5-T whole-body scanner and a T1-weighted fast-spin echo pulse sequence were used to collect multiple, contiguous axial images of the abdomen from a sample of 40 healthy adults (20 men) aged 18-77 years of age, with mean body mass index of 29 kg/m(2) (range = 19-43 kg/m(2)).Results: Hippo Fat (TM) provided estimates of VAT and SAT that were highly correlated with estimates using slice-O-matic (R-2 > 0.9). Average VAT was 9.4% lower and average SAT was 3.7% higher using Hippo Fat (TM) compared to slice-O-matic; the overestimation of SAT tended to be greater among individuals with greater adiposity. Individual-level differences for VAT were also substantial; Hippo Fat (TM) gave estimates of VAT ranging from 1184 cm(3) less to 566 cm(3) more than estimates for the same person using slice-O-matic.Conclusion: Hippo Fat (TM) provides a rapid method of quantifying total VAT, although the method does not provide estimates that are interchangeable with slice-O-matic at either the group (mean) or individual level.