Effect of iron fortification of infant formula on trace mineral absorption.
Effect of iron fortification of infant formula on trace mineral absorption.
复制标题
婴儿配方奶粉铁强化对微量矿物质吸收的影响。
DOI：
10.1097/00005176-198609000-00018
复制
发表时间：
1986
影响因子：
2.9
通讯作者：
Fomon,SJ
中科院分区：
文献类型：
--
作者：
Haschke,F;Ziegler,EE;Edwards,BB;Fomon,SJ
本研究旨在检测婴儿配方奶粉中的铁强化是否会影响其他营养素的利用，尤其是微量元素锌和铜。对7名年龄在43 - 420天之间的正常婴儿进行了代谢平衡研究。饲喂两种除铁浓度（10.2和2.5 mg/L）外组成几乎相同的配方奶粉。每个婴儿进行四次平衡研究，两次喂食配方奶粉10.2，两次喂食配方奶粉2.5，交替进行。配方奶粉铁浓度对氮、脂肪、钙和镁的吸收和/或保留没有明显影响。尽管配方10.2的磷吸收量显著（p < 0.05）低于配方2.5，但差异微不足道。未观察到对锌吸收的影响。然而，当喂食配方奶粉10.2时，铜的吸收量仅为摄入量的13.4%（标准差13.0），而喂食配方奶粉2.5时，铜的吸收量为摄入量的27.5%（标准差15.3）。当场发放问卷、填写和回收。两组比较差异有统计学意义（p < 0.01）。我们得出的结论是，铁强化配方奶粉中的铁含量对铜利用率有可测量的影响。由于影响的幅度相对较小，我们怀疑该发现是否具有临床相关性。
This study was designed to examine whether iron fortification of infant formulas has an effect on utilization of other nutrients, particularly the trace elements zinc and copper. Metabolic balance studies were performed with seven normal infants who were between 43 and 420 days of age. Two formulas of nearly identical composition except for iron concentration (10.2 and 2.5 mg/L) were fed. Each infant had four balance studies performed, two while being fed formula 10.2 and two while being fed formula 2.5, in an alternating sequence. No effect of formula iron concentration was evident on absorption and/or retention of nitrogen, fat, calcium, and magnesium. Although absorption of phosphorus was significantly (p < 0.05) less with formula 10.2 than formula 2.5, the difference was trivial. No effect on absorption of zinc was seen. However, absorption of copper was only 13.4% (SD 13.0) of intake when formula 10.2 was fed, compared with 27.5% (SD 15.3) of intake when formula 2.5 was fed. The difference was statistically significant (p < 0.01). We conclude that iron in amounts present in iron‐fortified formulas has a measurable effect on copper utilization. Because the magnitude of the effect is relatively small, we doubt that the finding is clinically relevant.