Polymers as biomaterials for tissue engineering and controlled drug delivery
Polymers as biomaterials for tissue engineering and controlled drug delivery
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DOI：
10.1007/b137240
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Laurencin, Cato T.
中科院分区：
文献类型：
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作者：
Nair, Lakshmi S.;Laurencin, Cato T.
生物可降解聚合物的出现显著影响了现代医学中各种技术的发展和快速增长。生物可降解聚合物主要用于需要材料暂时存在的地方，并且它们可用作缝合线、组织再生支架、组织粘合剂、止血剂和组织粘附的暂时屏障以及药物递送系统。这些应用中的每一个都需要具有独特的物理、化学、生物和生物力学特性的材料来提供有效的治疗。因此，广泛的可降解聚合物，天然的和合成的，已被研究用于这些应用。此外，分子和细胞生物学的最新进展，加上新的生物技术药物的开发，需要对现有聚合物进行改性或合成用于特定应用的新聚合物。这篇综述强调了目前研究的用于两个关键医学应用的各种可生物降解聚合物材料：药物递送和组织工程。
The advent of biodegradable polymers has significantly influenced the development and rapid growth of various technologies in modern medicine. Biodegradable polymers are mainly used where the transient existence of materials is required and they find applications as sutures, scaffolds for tissue regeneration, tissue adhesives, hemostats, and transient barriers for tissue adhesion, as well as drug delivery systems. Each of these applications demands materials with unique physical, chemical, biological, and biomechanical properties to provide efficient therapy. Consequently, a wide range of degradable polymers, both natural and synthetic, have been investigated for these applications. Furthermore, recent advances in molecular and cellular biology, coupled with the development of novel biotechnological drugs, necessitate the modification of existing polymers or synthesis of novel polymers for specific applications. This review highlights various biodegradable polymeric materials currently investigated for use in two key medical applications: drug delivery and tissue engineering.