EFFECT OF ZINC SUPPLEMENTATION ON COPPER STATUS IN ADULT MAN
EFFECT OF ZINC SUPPLEMENTATION ON COPPER STATUS IN ADULT MAN
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DOI：
10.1093/ajcn/40.4.743
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发表时间：
1984-01-01
影响因子：
7.1
通讯作者：
LABBE, MR
中科院分区：
文献类型：
--
作者：
FISCHER, PWF;GIROUX, A;LABBE, MR
通过测定铜金属酶、血浆铁氧化酶（铜蓝蛋白）和红细胞铜锌超氧化物歧化酶的活性，研究了锌对健康成年男性铜营养状况的影响。受试者每天服用2次25 mg Zn或安慰剂，共6 wk。在第2、4和6周，补充组和对照组之间的血浆铜水平或铁氧化酶活性没有显著差异。补锌组血浆锌含量升高，红细胞铜锌超氧化物歧化酶含量降低，至6周时两组间差异有显著性（P < 0.05）。这表明，锌补充剂降低了实验组的铜状态。
The effect of Zn supplementation on the Cu status of healthy adult men, as assessed by the activities of the Cu-metalloenzymes, plasma ferroxidase (ceruloplasmin), and erythrocyte Cu,Zn-superoxide dismutase, were determined. The subjects were given either 2 daily doses of 25 mg Zn or placebo for 6 wk. No significant differences in the plasma Cu levels or the ferroxidase activities between the supplemented and control groups could be detected at 2, 4 or 6 wk. Plasma Zn increased and erythrocyte Cu,Zn-superoxide dismutase decreased in the supplemented group, the difference between the groups becoming significant at 6 wk (P < 0.05). This suggested that the Zn supplements decreased the Cu status of the experimental group.