Regional cerebral blood flow and cerebrovascular risk factors in the elderly population
Regional cerebral blood flow and cerebrovascular risk factors in the elderly population
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DOI：
10.1016/s0197-4580(98)00004-9
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发表时间：
1998-01-01
影响因子：
4.2
通讯作者：
Hofman, A
中科院分区：
文献类型：
--
作者：
Claus, JJ;Breteler, MMB;Hofman, A
用~(99m)Tm标记的六甲基丙二胺肟单光子发射计算机断层扫描对60例老年人(年龄65~84岁)的局部脑血流量(RCBF)进行了研究。我们调查了是否只有年龄影响rCBF，或者是否可以确定其他因素可以解释这种关系。多元线性回归分析显示，随着年龄的增加，顶叶、顶叶和颞叶皮质的rCBF显著降低，而额叶皮质的rCBF减少不明显。调整高血压、心肌梗塞病史、VIIC因子、VIIIc因子、胆固醇和高密度脂蛋白、吸烟、糖尿病等脑血管疾病危险因素对这些关系无影响。相反，在调整了纤维蛋白原和颈动脉粥样硬化指标(包括颈动脉内中膜厚度和颈动脉斑块)后，年龄和rCBF之间的相关性不再具有统计学意义。根据皮质萎缩的局部分级进行校正并不影响年龄和rCBF之间的关系。结果表明，在老年人群中，后部皮质区域的rCBF随着年龄的增长而下降，这些变化可以很好地用动脉粥样硬化的存在来解释。动脉粥样硬化导致的血管肌壁的收缩能力随年龄增长而降低可能是其潜在的机制。(C)1998年爱思唯尔科学公司。
Regional cerebral blood flow (rCBF) was studied in 60 elderly persons (aged 65 to 84 years) recruited from a population-bated study, with single photon emission computed tomography using technetium 99m-labeled hexamethylpropylene amine oxime. We investigated whether it is only age that affects rCBF or whether other factors can be indentified that explain this relationship. Using multiple linear regression analysis, increasing age was significantly associated with rCBF decrease in parietal, temporo-parietal, and temporal cortex, but not in frontal cortex. Adjustment with several risk factors for cerebrovascular disease, including hypertension, history of myocardial infarction, factor VIIc, factor VIIIc, cholesterol and HDL cholesterol, smoking, and diabetes mellitus had no influence on these relations. Conversely, the association between age and rCBF was no longer statistically significant after adjustment with fibrinogen and indicators of carotid atherosclerosis, including intima-media wall thickness of the carotid artery and plaques in the carotid artery. Correction with local ratings of cortical atrophy did not affect the relations between age and rCBF. The results suggest that in the elderly population rCBF declines with age in posterior cortical areas and that these changes may well be explained by the presence of atherosclerosis. Reduced contractility of the vascular muscle wall with increasing age resulting from atherosclerosis may be the underlying mechanism. (C) 1998 Elsevier Science Inc.