From the connectome to brain function
From the connectome to brain function
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DOI：
10.1038/nmeth.2451
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发表时间：
2013-06-01
期刊：
影响因子：
48
通讯作者：
Marder, Eve
中科院分区：
文献类型：
--
作者：
Bargmann, Cornelia I.;Marder, Eve
在这个历史的角度来看，我们问什么信息是需要超越连接图，以了解神经系统的功能。无脊椎动物电路的连通性是已知的，我们强调神经元动力学和神经调节的重要性，以及并行电路的存在。脊椎动物的视网膜具有与无脊椎动物电路相同的这些特征，这表明它们在动物中普遍存在。这些系统之间的比较建议的方法来研究大型电路的功能组织的基础上现有的知识小电路。
In this Historical Perspective, we ask what information is needed beyond connectivity diagrams to understand the function of nervous systems. Informed by invertebrate circuits whose connectivities are known, we highlight the importance of neuronal dynamics and neuromodulation, and the existence of parallel circuits. The vertebrate retina has these features in common with invertebrate circuits, suggesting that they are general across animals. Comparisons across these systems suggest approaches to study the functional organization of large circuits based on existing knowledge of small circuits.