Behavior and Stress Reactivity in Mouse Strains with Mitochondrial DNA Variations
Behavior and Stress Reactivity in Mouse Strains with Mitochondrial DNA Variations
复制标题
DOI：
10.1111/j.1749-6632.2008.03960.x
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Ibrahim, Saleh M.
中科院分区：
文献类型：
--
作者：
Gimsa, Ulrike;Kanitz, Ellen;Ibrahim, Saleh M.
本研究以AKR/J和FVB/N品系的线粒体替代C57 BL/6 J小鼠，研究其在社会破坏应激下的行为和神经内分泌调节。C57 BL/6 J-mt（FVB/N）小鼠在高架十字迷宫实验中的焦虑程度显著高于C57 BL/6 J-mt（AKR/J）和C57 BL/6 J小鼠。此外，在反复激发后，他们显示出皮质酮反应降低以及多巴胺能和多巴胺能神经递质系统的激活，即，社交失败和高架十字迷宫测试。我们的研究结果表明，线粒体变异可能会影响焦虑样行为以及皮质酮和神经递质对心理压力的反应。
We studied the behavior and neuroendocrine regulation under social disruption stress of C57BL/6J mice in which mitochondria were substituted by mitochondria from AKR/J or FVB/N strains. C57BL/6J-mt(FVB/N) mice were significantly more anxious in the elevated plus-maze test than C57BL/6J-mt(AKR/J) and C57BL/6J mice at base line. In addition, they showed a reduced corticosterone response and an activation of serotonergic and dopaminergic neurotransmitter systems after repeated challenge, i.e., social defeat and elevated plus-maze test. Our findings suggest that mitochondrial variations could affect anxiety-like behavior as well as corticosterone and neurotransmitter response to psychological stress.