Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
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DOI：
10.1248/bpb.23.1481
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发表时间：
2000-12-01
影响因子：
2
通讯作者：
Kim, DH
中科院分区：
文献类型：
--
作者：
Bae, EA;Park, SY;Kim, DH
当将β-葡糖苷R-b1和R-b2与人肠道微生物菌群厌氧孵育时，这些β-葡糖苷被代谢为20-O-β-D-吡喃葡萄糖基-20（S）-原人参二醇（化合物K）和20（S）-原人参二醇。几种肠道细菌水解这些糖苷。真杆菌属，链球菌属和双歧杆菌属，其更有效地水解龙胆二糖而不是槐糖，通过GTR-d而不是绞股蓝皂苷XVII将GTR-b1代谢为化合物K。然而，比龙胆二糖更有效水解槐糖的梭杆菌K-60通过绞股蓝皂苷XVII代谢为化合物K。人参皂苷R-b2在人体肠道菌群中也可经β-D-受体代谢为化合物K或化合物O。真杆菌属，链球菌属和双歧杆菌属通过BCR-d而不是化合物O代谢BCR-b 2为化合物K。Fusobacterium K-60通过化合物O代谢BCR-b2生成化合物K。
When ginsenoside R-b1 and R-b2 were anaerobically incubated with human intestinal microflora, these ginsenosides were metabolized to 20-O-beta -D-glucopyranosyl-20(S)-protopanaxadiol (compound K) and 20(S)-protopanaxadiol. Several kinds of intestinal bacteria hydrolyzed these ginsenosides. Eubacterium sp., Streptococcus sp. and Bifidobacterium sp., which more potently hydrolyzed gentiobiose than sophorose, metabolized ginsenoside R-b1 to compound K via ginsenoside R-d rather than gypenoside XVII. However, Fusobacterium K-60, which more potently hydrolyzed sophorose than gentiobiose, metabolized to compound K via gypenoside XVII. Ginsenoside R-b2 was also metabolized to compound K via ginsenoside R-d or compound O by human intestinal microflora. Eubacterium sp., Streptococcus sp. and Bifidobacterium sp. metabolized ginsenoside R-b2 to compound K via ginsenoside R-d rather than compound O. Fusobacterium K-60 metabolized ginsenoside R-b2 to compound K via compound O.