Processing and Characterization of Silicon Nitride Bioceramics
Processing and Characterization of Silicon Nitride Bioceramics
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氮化硅生物陶瓷的加工和表征
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
D. O’Brien
中科院分区：
文献类型：
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作者：
B. McEntire;R. Lakshminarayanan;Prabhakar Thirugnanasamb;Jacob W. Seitz;R. Bock;D. O’Brien
作为一种相对较新的生物材料，氮化硅（Si3N4）目前被用作颈椎和胸腰椎的关节固定器械，并且正在考虑将其作为全关节置换术中的关节面材料。在本文中，开发和验证的生产过程中使用的Si3N4生物医学植入物的介绍和讨论。在专门用于此目的的工厂中进行制造，使用设计用于通过传统干压、绿色状态下组件的CNC加工、烧结和热等静压产生净形椎间融合器的工艺。这些生产方法采用Taguchi部分析因实验设计进行工业化，然后实施统计过程控制。各种加工参数的作用，包括原料、压制和烧制条件（即，时间、温度和压力）。对于这些器械，经证明，通过精心设计和统计学控制的过程，可始终获得可接受的物理、机械和尺寸特性。
As a relatively new biomaterial, silicon nitride (Si3N4) is currently used as an arthrodesis device in the cervical and thoracolumbar spine, and it is under consideration as a bearing material in total joint arthroplasty. In this paper, the development and validation of the manufacturing processes used in the production of Si3N4 biomedical implants are presented and discussed. Manufacturing was conducted in a facility specifically dedicated for this purpose using processes designed to yield net shape intervertebral spinal spacers by conventional dry-pressing, CNC machining of components in the green state, sintering, and hot isostatic pressing. These manufacturing methods were industrialized using Taguchi fractional factorial experimental designs, followed by implementation of statistical process controls. The roles of various processing parameters including raw materials, pressing, and firing conditions (i.e., time, temperature, and pressure) are elucidated. For these devices, it was demonstrated that acceptable physical, mechanical, and dimensional properties were consistently obtained from carefully designed and statistically controlled processes.