The conserved fission complex on peroxisomes and mitochondria
The conserved fission complex on peroxisomes and mitochondria
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DOI：
10.4161/psb.6.6.15241
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Hu, Jianping
中科院分区：
文献类型：
--
作者：
Pan, Ronghui;Hu, Jianping
过氧化物酶体是真核生物的细胞器，其含量和丰度具有高度的多样性和动态性。植物过氧化物酶体介导多种代谢途径，其中许多在过氧化物酶体和其他亚细胞器（包括线粒体和叶绿体）中依次完成。为了了解过氧化物酶体动力学如何促进植物生理和适应的变化，过氧化物酶体的增殖途径正在被解剖。在拟南芥中的研究已经确定了几个进化上保守的过氧化物酶体分裂蛋白质家族。这些包括诱导过氧化物酶体延伸和裂变机制的五种过氧化物酶11蛋白（PEX 11 a至-e），其由三种动力蛋白相关蛋白（DRP 3A、DRP 3B和DRP 5 B）和DRP的膜受体FISION 1（FIS 1A和FIS 1B）组成。虽然PEX 11的功能仅限于过氧化物酶体，但裂变因子更混杂。DRP 3和FIS 1蛋白在过氧化物酶体和线粒体之间共享，DRP 5 B在叶绿体和过氧化物酶体的分裂中起双重作用。对拟南芥基因组的分析表明，高等植物可能也含有酵母Mdv 1/Caf 4蛋白的功能同源物，这些蛋白是将DRPs连接到过氧化物酶体和线粒体膜上的FIS 1的衔接蛋白。在整个进化过程中，这些代谢相关的亚细胞区室之间共享一个保守的裂变机可能具有一些生物学意义。
Peroxisomes are eukaryotic organelles highly versatile and dynamic in content and abundance. Plant peroxisomes mediate various metabolic pathways, a number of which are completed sequentially in peroxisomes and other subcellular organelles, including mitochondria and chloroplasts. To understand how peroxisomal dynamics contribute to changes in plant physiology and adaptation, the multiplication pathways of peroxisomes are being dissected. Research in Arabidopsis thaliana has identified several evolutionarily conserved families of proteins in peroxisome division. These include five PEROXIN11 proteins (PEX11a to -e) that induce peroxisome elongation and the fission machinery, which is composed of three dynamin-related proteins (DRP3A, -3B and -5B) and DRP's membrane receptor, FISSION1 (FIS1A and -1B). While the function of PEX11 is restricted to peroxisomes, the fission factors are more promiscuous. DRP3 and FIS1 proteins are shared between peroxisomes and mitochondria, and DRP5B plays a dual role in the division of chloroplasts and peroxisomes. Analysis of the Arabidopsis genome suggests that higher plants may also contain functional homologs of the yeast Mdv1/Caf4 proteins, adaptor proteins that link DRPs to FIS1 on the membrane of both peroxisomes and mitochondria. Sharing a conserved fission machine between these metabolically linked subcellular compartments throughout evolution may have some biological significance.