AUTONOMIC RESPONSE TO CORONARY-OCCLUSION IN ANIMALS SUSCEPTIBLE TO VENTRICULAR-FIBRILLATION
AUTONOMIC RESPONSE TO CORONARY-OCCLUSION IN ANIMALS SUSCEPTIBLE TO VENTRICULAR-FIBRILLATION
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DOI：
10.1152/ajpheart.1989.257.6.h1886
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发表时间：
1989-12-01
影响因子：
--
通讯作者：
BILLMAN, GE
中科院分区：
文献类型：
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作者：
COLLINS, MN;BILLMAN, GE
心肌缺血期间自主神经控制的紊乱可能会显着促进恶性心律失常的发生。因此，在运动试验中，29只心肌梗塞已治愈的杂种狗被诱发急性缺血。 17 只动物出现心室颤动（易感，S），而 12 只狗没有出现心室颤动（抵抗，R）。在运动加缺血试验之前，在休息时进行冠状动脉闭塞。呼吸性窦性心律失常的振幅（R-R间期波动的0.24至1.04Hz分量）被用作心脏迷走神经张力的指标。急性缺血引起易感动物心率显着增加（S：对照 115.6 +/- 0.8，闭塞 176.4 +/- 8.2 次/分钟 vs. R：对照 114.6 +/- 8.9，闭塞 145.7 +/- 7.5 次/分钟）。伴随着心率的增加，易感动物的心脏迷走神经张力指数显着降低。 （S：控制 6.4 +/- 0.3，闭塞 2.2 +/- 0.6 ln ms2 对比 R：控制 6.6 +/- 0.4，闭塞 5.1 +/- 0.5 ln ms2）。 β-肾上腺素能受体阻断减少了心率的增加，但加剧了心脏迷走神经张力指数的降低。这些数据表明，冠状动脉闭塞会引起动物交感神经活动显着增加，同时副交感神经活动显着减少，随后显示出对心室颤动敏感。
Disturbances in autonomic control during myocardial ischemia may contribute significantly to the development of malignant cardiac arrhythmias. Therefore acute ischemia was induced in 29 mongrel dogs with healed myocardial infarctions during an exercise test. Seventeen animals developed ventricular fibrillation (susceptible, S), whereas 12 dogs did not (resistant, R). Before the exercise plus ischemia test a coronary occlusion was made at rest. The amplitude of respiratory sinus arrhythmia (0.24- to 1.04-Hz component of R-R interval fluctuation) was used as an index of cardiac vagal tone. Acute ischemia elicited a significantly larger heart rate increase in susceptible animals (S: control 115.6 +/- 0.8, occlusion 176.4 +/- 8.2 beats/min vs. R: control 114.6 +/- 8.9, occlusion 145.7 +/- 7.5 beats/min). Accompanying the heart rate increase were significantly greater reductions in the cardiac vagal tone index in the susceptible animals. (S: control 6.4 +/- 0.3, occlusion 2.2 +/- 0.6 ln ms2 vs. R: control 6.6 +/- 0.4, occlusion 5.1 +/- 0.5 ln ms2). beta-Adrenergic receptor blockade reduced the heart rate increases but exacerbated the reductions in the cardiac vagal tone index. These data suggest that coronary artery occlusion elicits a significantly greater increase in sympathetic activity coupled with a greater reduction in parasympathetic activity in animals subsequently shown to be susceptible to ventricular fibrillation.