HISTIDINE-RICH PROTEIN OF THE KERATOHYALIN GRANULES - SOURCE OF THE FREE AMINO-ACIDS, UROCANIC ACID AND PYRROLIDONE CARBOXYLIC-ACID IN THE STRATUM-CORNEUM
HISTIDINE-RICH PROTEIN OF THE KERATOHYALIN GRANULES - SOURCE OF THE FREE AMINO-ACIDS, UROCANIC ACID AND PYRROLIDONE CARBOXYLIC-ACID IN THE STRATUM-CORNEUM
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DOI：
10.1016/0304-4165(82)90314-2
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
BARRETT, JG
中科院分区：
文献类型：
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作者：
SCOTT, IR;HARDING, CR;BARRETT, JG
哺乳动物[豚鼠]角质层中的游离氨基酸、尿刊酸和吡咯烷酮羧酸库主要或全部源自透明角质颗粒的富含组氨酸的蛋白质。游离氨基酸出现的时间过程和富含组氨酸的蛋白质的分解是相似的，游离氨基酸和富含组氨酸的蛋白质的分析也是相似的。定量研究表明，角质层总游离氨基酸的 70% 至 100% 来自富含组氨酸的蛋白质。
The pool of free amino acids, urocanic acid and pyrrolidonecarboxylic acid in mammalian [guinea pig] stratum corneum is derived principally or totally from the histidine-rich protein of the keratohyalin granules. The time course of appearance of free amino acids and breakdown of the histidine-rich protein are similar, as are the analyses of the free amino acids and histidine-rich protein. Quantitative studies show that between 70 and 100% of the total stratum corneum-free amino acids are derived from the histidine-rich protein.