Risk Factor Differences for Aortic Versus Coronary Calcified Atherosclerosis The Multiethnic Study of Atherosclerosis
Risk Factor Differences for Aortic Versus Coronary Calcified Atherosclerosis The Multiethnic Study of Atherosclerosis
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DOI：
10.1161/atvbaha.110.208181
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发表时间：
2010-11-01
影响因子：
8.7
通讯作者：
Wong, Nathan D.
中科院分区：
文献类型：
--
作者：
Criqui, Michael H.;Kamineni, Aruna;Wong, Nathan D.
本研究的目的是比较和对比冠状动脉钙（CAC）与腹主动脉钙（AAC）在其与传统的和新的心血管疾病（CVD）的危险factors.Methods和Results-We测量AAC和CAC使用计算机断层扫描在1974年男性和女性年龄在45至84岁的多种族队列。分别检查了与AAC和CAC相关的传统和新型心血管疾病危险因素，使用逻辑回归进行定性分类比较，使用多元线性回归进行定量连续比较。AAC与吸烟和血脂异常显著相关，且无性别差异。与此相反，CAC与吸烟和血脂异常的相关性要弱得多，男性占主导地位。年龄和高血压与AAC和CAC的相关性相似且显著。新的危险因素通常与钙测量没有独立的关联，尽管在子集分析中，磷而不是钙与CAC相关。AAC的定性结果的受试者操作特征曲线和定量分析的r（2）值均远高于CAC。结论AAC与大多数CVD危险因素的相关性比CAC更强。与CAC相比，AAC对新发CVD事件的预测价值仍有待评估。（Arterioscler Thromb Vasc Biol.2010;30：2289-2296.）
Objective-The goal of this study was to compare and contrast coronary artery calcium (CAC) with abdominal aortic calcium (AAC) in terms of their associations with traditional and novel cardiovascular disease (CVD) risk factors.Methods and Results-We measured both AAC and CAC using computed tomography scans in 1974 men and women aged 45 to 84 years from a multiethnic cohort. Traditional and novel CVD risk factors were examined separately in relation to AAC and CAC, using logistic regression for qualitative categorical comparisons and multiple linear regression for quantitative continuous comparisons. AAC was significantly associated with cigarette smoking and dyslipidemia and showed no gender difference. In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. Age and hypertension were associated similarly and significantly with AAC and CAC. Novel risk factors generally showed no independent association with either calcium measure, although in subset analyses, phosphorus, but not calcium, was related to CAC. The receiver operating characteristic curves for the qualitative results and the r(2) values for the quantitative analyses were both much higher for AAC than for CAC.Conclusion-AAC showed stronger correlations with most CVD risk factors than did CAC. The predictive value of AAC compared with CAC for incident CVD events remains to be evaluated. (Arterioscler Thromb Vasc Biol. 2010;30:2289-2296.)