A population-based, cross-sectional survey of the Zuni Pueblo: A collaborative approach to an epidemic of kidney disease
A population-based, cross-sectional survey of the Zuni Pueblo: A collaborative approach to an epidemic of kidney disease
复制标题
DOI：
10.1053/ajkd.2002.30557
复制
发表时间：
2002-02-01
影响因子：
13.2
通讯作者：
Zager, PG
中科院分区：
文献类型：
--
作者：
Stidley, CA;Shah, VO;Zager, PG
大约80%的祖尼印第安人生活在新墨西哥州农村的祖尼普韦布洛。祖尼人是相对内婚制的，在文化和种族上与邻近部落不同。祖尼普韦布洛正在经历一场肾脏疾病的流行。根据年龄和性别进行调整后，祖尼印第安人的终末期肾病(ESRD)患病率分别比美洲原住民和欧洲裔美国人的患病率高出6倍和21倍。几乎所有祖尼部落成员都有患有ESRD的亲戚。这导致了公众对肾脏研究的强烈支持。作为回应，祖尼社区与印度卫生服务(IHS)、新墨西哥大学健康科学中心(UNHSC)、西南生物医学研究基金会(SFBR)、透析诊所公司(DCI)和国家卫生研究院(NIH)合作，建立了一个研究财团--祖尼肾脏项目(ZKP)。ZKP的目标是减轻祖尼社区的肾脏疾病负担。ZKP将传统的、基于人口的流行病学方法与现代人口遗传学技术相结合。ZKP的基础是以人口为基础的横断面调查(PBCS)。PBSS有3项具体措施：(1)评估Zuni的肾脏疾病患病率；(2)评估肾脏疾病易感性的风险因素；(3)确定计划病例对照、纵向队列和家族性研究的参与者，旨在确定导致肾脏疾病易感性和/或进展的环境、家族和遗传风险因素。PBCS的初步结果证实，祖尼印第安人肾脏疾病的流行是由于糖尿病和非糖尿病肾脏疾病的高发病率。(C)2002年，由国家肾脏基金会公司提供。
Approximately 80% of the Zuni Indians live in Zuni Pueblo in rural New Mexico. The Zuni are relatively endogamous and differ culturally and ethnically from neighboring tribes. The Zuni Pueblo is experiencing an epidemic of renal disease. The prevalence of end-stage renal disease (ESRD) among the Zuni Indians, adjusted for age and gender, Is 6-fold and 21-fold higher than the prevalence rates for Native Americans and European Americans. Almost all Zuni tribal members have a relative with ESRD. This has led to strong public support for renal research. In response, the Zuni community has partnered with the Indian Health Service (IHS), University of New Mexico Health Sciences Center (UNMHSC), Southwest Foundation for Biomedical Research (SFBR), Dialysis Clinic Inc (DCI), and the National Institutes of Health (NIH) to establish a research consortium, the Zuni Kidney Project (ZKP). The goal of the ZKP is to reduce the burden of renal disease in the Zuni community. The ZKP combines traditional, population-based, epidemiologic methods with modern techniques of population genetics. The foundation of the ZKP is a population-based, cross-sectional survey (PBCSS). The PBCSS has 3 specific alms: (1) estimate the prevalence of renal disease In Zuni; (2) assess risk factors for renal disease susceptibility; and (3) Identify participants for planned case-control, longitudinal cohort, and family studies designed to Identify environmental, familial, and genetic risk factors for the susceptibility and/or progression of renal disease. Preliminary results of the PBCSS confirm that the epidemic of renal disease in Zuni Indians Is due to high rates of both diabetic and nondiabetic renal disease. (C) 2002 by the National Kidney Foundation, Inc.