Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents
Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents
复制标题
高性能磁热疗剂 Fe3O4 纳米粒子表面涂层的优化
DOI：
10.1039/c2jm30472d
复制
发表时间：
2012-01-01
影响因子：
--
通讯作者：
Ding, Jun
中科院分区：
文献类型：
--
作者：
Liu, Xiao Li;Fan, Hai Ming;Ding, Jun
已成功合成具有受控粒径和 mPEG 表面涂层的高度单分散磁铁矿纳米颗粒作为模型系统，以研究交变磁场下表面涂层对比吸收率 (SAR) 的影响。观察到随着表面涂层厚度的减小，比吸收率增强，这归因于布朗损失的增加、导热性的改善以及分散性的改善。通过对表面涂层和颗粒尺寸进行精心优化，可以在饱和磁化强度变化最小（<5%）的情况下实现比吸收率的显着提高（高达 74%）。特别是，19nm@2000 样品在样品中表现出最高的 SAR，为 930 W g−1。此外，这种高加热能力可以在各种模拟生理条件下保持。我们的结果为高性能热疗剂的磁芯表面涂层优化提供了通用策略。
Highly monodispersed magnetite nanoparticles with controlled particle size and mPEG surface coating have been successfully synthesized as a model system to investigate the effect of surface coating on the specific absorption rate (SAR) under an alternating magnetic field. Enhanced SAR with decreased surface coating thickness was observed and ascribed to the increased Brownian loss, improved thermal conductivity as well as improved dispersibility. By elaborate optimization of the surface coating and particle size, a significant increase of SAR (up to 74%) could be achieved with a minimal variation of the saturation magnetization (<5%). In particular, the 19nm@2000 sample exhibited the highest SAR of 930 W g−1 among the samples. Furthermore, this high heating capacity can be maintained in various simulated physiological conditions. Our results provide a general strategy for surface coating optimization of magnetic cores for high performance hyperthermia agents.