Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host
Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host
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造血干细胞生成失败是免疫功能低下宿主因巨细胞病毒病死亡的主要原因
DOI：
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发表时间：
1988
影响因子：
15.3
通讯作者：
Ulrich H. Koszinowski
中科院分区：
文献类型：
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作者：
W. Mutter;M. Reddehase;Busch Fw;H. Bühring;Ulrich H. Koszinowski
我们已经在免疫功能低下宿主巨细胞病毒（CMV）疾病的小鼠模型系统中显示，CMV感染干扰造血中最早可检测的步骤，即干细胞CFU-S-I的产生，从而防止亚致死照射后骨髓的自动重建。抗造血作用不能归因于干细胞的直接感染。抗病毒CD 8 + T淋巴细胞过继转移可预防造血功能衰竭，同基因骨髓移植可克服造血功能衰竭。CD 8 + T淋巴细胞和骨髓细胞都介导存活，尽管只有CD 8 + T淋巴细胞能够限制宿主组织中的病毒增殖。我们的结论是，不是病毒在宿主组织中复制的致细胞病变效应，而是造血功能的失败，是小鼠CMV病死亡的主要原因。
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the autoreconstitution of bone marrow after sublethal irradiation. The antihemopoietic effect could not be ascribed to a direct infection of stem cells. The failure in hemopoiesis was prevented by adoptive transfer of antiviral CD8+ T lymphocytes and could be overcome by syngeneic bone marrow transplantation. CD8+ T lymphocytes and bone marrow cells both mediated survival, although only CD8+ T lymphocytes were able to limit virus multiplication in host tissues. We concluded that not the cytopathic effect of virus replication in host tissues, but the failure in hemopoiesis, is the primary cause of death in murine CMV disease.
源自贴壁鼠骨髓细胞的细胞系 (TC-1) 产生造血因子。
影响因子：
20.3
作者：
Song,ZX;Shadduck,RK;InnesJr,DJ;Waheed,A;Quesenberry,PJ
通讯作者：
Quesenberry,PJ
骨髓移植后巨细胞病毒感染：风险、治疗和预防。
DOI：
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发表时间：
1984
期刊：
Birth defects original article series
影响因子：
--
作者：
Meyers,JD
通讯作者：
Meyers,JD
鼠巨细胞病毒感染后的巨核细胞生成和粒细胞生成。
DOI：
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发表时间：
1984
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Petursson,SR;Chervenick,PA;Wu,B
通讯作者：
Wu,B