BASE-LINE AND FEAR-POTENTIATED STARTLE IN PANIC DISORDER PATIENTS
BASE-LINE AND FEAR-POTENTIATED STARTLE IN PANIC DISORDER PATIENTS
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DOI：
10.1016/0006-3223(94)90040-x
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发表时间：
1994-04-01
影响因子：
10.6
通讯作者：
DAVIS, M
中科院分区：
文献类型：
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作者：
GRILLON, C;AMELI, R;DAVIS, M
本研究调查了惊恐障碍患者的惊吓反应是否增加，以及这种影响是否存在，是特定于预期焦虑。在34例惊恐障碍患者和49名健康对照者中，测量了听觉惊吓反射的眨眼成分，该范式涉及电击（恐惧增强惊吓）的预期。在测试开始和结束时，在没有特定威胁的情况下也记录了惊吓。测试包括三个阶段：适应，恐惧增强惊吓和恢复。在适应和恢复阶段，惊吓刺激是在没有威胁的情况下提供的。在恐惧增强惊吓阶段，惊吓刺激在威胁条件下，当受试者预期的冲击，并在安全的条件下，预测没有冲击。在整个测试过程中，与年轻对照组相比，年轻患者（年龄< 40岁）的惊吓程度更大。然而，这种差异只在恐惧增强的惊吓阶段才达到显著性。与老年对照组相比，老年患者（年龄大于或等于39岁）的惊吓无显著减少。结果进行了讨论的实验设置的上下文效果。
The present study investigated whether patients with panic disorder had an increase in the startle response and whether this effect if present, was specific to anticipatory anxiety. The eyeblink component of the acoustic startle reflex was measured in a paradigm involving the anticipation of electric shocks (fear-potentiated startle) in 34 patients with panic disorder and 49 healthy controls. Startle was also recorded in the absence of specific threat at the beginning and at the end of the testing. The testing consisted of three phases: adaptation, fear-potentiated startle, and recovery. In the adaptation and recovery phases, startle stimuli were delivered in the absence of threat. In the fear-potentiated startle phase, startle stimuli were delivered in threat conditions, when subjects anticipated shocks, and in safe conditions that predicted the absence of shocks. Startle was larger in the younger patients (age < 40 years old) compared to the younger controls throughout the testing. The difference reached significance only during the fear-potentiated startle phase, however. Startle was nonsignificantly reduced in the older patients (age greater than or equal to 39 years old), compared to the older controls. The results are discussed in terms of the contextual effects of the experimental setting.