Effect of prolonged starvation on reticuloendothelial function and survival following trauma.
Effect of prolonged starvation on reticuloendothelial function and survival following trauma.
复制标题
长期饥饿对网状内皮功能和创伤后生存的影响。
DOI：
10.1097/00005373-198108000-00003
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Baue,AE
中科院分区：
文献类型：
--
作者：
Chaudry,IH;Schleck,S;Kovacs,KF;Baue,AE
研究了长期饥饿对网状内皮系统（RE）功能和创伤后动物存活的影响。将大鼠禁食51/2天（自由饮水），之后在中线切开2cm并结扎盲肠（CL）。CL后36小时允许食物和水，并在5天内测量存活率。这些动物的死亡率为60%（15/25），而禁食24小时的CL大鼠的死亡率为0%（0/15）。单独饥饿7天未导致任何死亡，但饥饿11天后死亡率为100%。另一组动物禁食5%天，并用于研究CL后10小时的RE功能。各组动物注射脂肪乳剂的血管内清除率无显著差异，表明长时间饥饿加CL（SCL）未改变总吞噬功能。然而，SLC后，脾脏中的乳剂保留（以每克组织注射剂量的百分比表示）减少了53%，肺保留增加了988%。血清GOT水平不受长期饥饿的影响;然而，SCL导致其升高（37与82 IU/ml）。肝脏ATP水平（[mu] mol/g）从2.47下降到1.95饥饿51/2天后，SCL后，它下降到1.75。这些结果表明，创伤（即CL）后代谢需求增加，加上长期饥饿，改变了RE功能，脾脂肪乳剂摄取减少，肺摄取增加。这些发现与免疫功能的关系仍有待确定。虽然死亡率增加的确切原因尚不清楚，但代谢和RE功能的改变可能起作用。
The effects of prolonged starvation on reticuloendothelial system (RE) function and on the survival of animals following trauma were studied. Rats were fasted for 51/2 days (water ad lib) after which a two-cm midline incision was made and the cecum ligated (CL). Food and water were allowed 36 hr after CL and survival was measured over 5 days. The mortality rate in these animals was 60%(15/25) compared to 0%(0/15) in CL rats fasted for 24 hr. Starvation alone for 7 days did not produce any deaths but after 11 days of starvation mortality was 100%. Another group of animals were fasted for 5% days and were used to study RE function 10 hr following CL. There was no significant difference in the intravascular clearance rates of injected lipid emulsion in various groups of animals, indicating that total phagocytic function was not changed by prolonged starvation plus CL (SCL). However, emulsion retention in the spleen, expressed as per cent injected dose per gm tissue, decreased by 53% and the lung retention increased by 988% following SLC. Serum GOT levels were not affected by prolonged starvation alone; however, SCL resulted in its elevation (37 vs. 82 IU/ml). Hepatic ATP levels ([mu] moles/g) decreased from 2.47 to 1.95 following 51/2 days starvation and following SCL, it decreased to 1.75. These results indicate that the increased metabolic demand following trauma (ie, CL), coupled with prolonged starvation, alters RE function with splenic lipid emulsion uptake decreasing and pulmonary uptake increasing. The relationship of these findings to immune function remains to be determined. Although the precise cause of increased mortality is not known, altered metabolic and RE function may play a role.