Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats
Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats
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DOI：
10.1016/j.bbr.2006.01.008
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发表时间：
2006-05-15
影响因子：
2.7
通讯作者：
Bimonte-Nelson, HA
中科院分区：
文献类型：
--
作者：
French, KL;Granholm, ACE;Bimonte-Nelson, HA
胆碱能系统参与认知和几种形式的痴呆症，包括阿尔茨海默病，尼古丁给药已被证明可以改善人类和啮齿动物的认知能力。虽然人体实验表明尼古丁可以提高处理工作记忆负荷增加的能力，但在动物模型中，随着工作记忆负荷的增加，评估尼古丁对表现的影响的工作很少。在这份报告中，我们证明，在老年大鼠尼古丁提高了处理不断增加的工作记忆负荷的能力，以及提高性能的参考记忆组成部分的水径向臂迷宫任务。发挥这些作用所需的剂量（0.3 mg/kg/天）远低于在幼龄大鼠中显示有效的剂量，并且似乎是比在轻度至中度吸烟者中观察到的维持剂量更低的剂量。此外，我们的研究报告了尼古丁诱导的老年大鼠海马神经生长因子（NGF）蛋白水平的降低。尼古丁对海马神经生长因子水平的影响进行了讨论，作为尼古丁诱导的工作记忆和参考记忆改善的潜在机制。(C)2006 Elsevier B. V.保留所有权利。
The cholinergic system is involved in cognition and several forms of dementia, including Alzheimer's disease, and nicotine administration has been shown to improve cognitive performance in both humans and rodents. While experiments with humans have shown that nicotine improves the ability to handle an increasing working memory load, little work has been done in animal models evaluating nicotine effects on performance as working memory load increases. In this report, we demonstrate that in aged rats nicotine improved the ability to handle an increasing working memory load as well as enhanced performance on the reference memory component of the water radial arm maze task. The dose required to exert these effects (0.3 mg/kg/day) was much lower than doses shown to be effective in young rats and appears to be a lower maintenance dose than is seen in light to moderate smokers. In addition, our study reports a nicotine-induced reduction in nerve growth factor (NGF) protein levels in the hippocampus of the aged rat. The effects of nicotine on hippocampal NGF levels are discussed as a potential mechanism of nicotine-induced improvements in working and reference memory. (C) 2006 Elsevier B.V. All rights reserved.