Threshold and subthreshold generalized anxiety disorder among US adolescents: prevalence, sociodemographic, and clinical characteristics.
Threshold and subthreshold generalized anxiety disorder among US adolescents: prevalence, sociodemographic, and clinical characteristics.
复制标题
DOI：
10.1017/s0033291713002997
复制
发表时间：
2014-08
影响因子：
6.9
通讯作者：
Merikangas, K. R.
中科院分区：
文献类型：
--
作者：
Burstein, M.;Beesdo-Baum, K.;He, J. -P.;Merikangas, K. R.
广泛性焦虑症（GAD）的阈值和阈值以下形式在成年人中非常普遍且具有损害性。然而，很少有一般人群研究检查生命早期的这些状况。本研究的主要目标是：(1) 在美国青少年的全国代表性样本中，检查阈值和阈下形式的广泛性焦虑症的患病率、社会人口统计学和临床特征； (2) 测试阈值和阈下疾病形式之间社会人口统计学和临床特征的差异。国家合并症调查青少年补充资料是一项具有全国代表性的面对面调查，对象为美国大陆 10123 名 13 至 18 岁青少年。大约 3% 的青少年符合 GAD 阈值标准。将所需的持续时间从 6 个月减少到 3 个月，导致患病率增加 65.7% (5.0%)；进一步放宽不可控标准导致患病率额外增加 20.7%（6.1%）。患有各种形式的广泛性焦虑症的青少年都表现出反复发作的临床病程，其特点是严重损害和与其他精神疾病的共病。 GAD 阈值和阈下病例之间的社会人口统计学和临床特征几乎没有显着差异。结果还揭示了 GAD 相关症状和临床病程与年龄相关的差异。研究结果证明了青少年中阈下形式的 GAD 的临床意义，强调了 GAD 结构的连续性。年龄相关的广泛性焦虑症相关症状和临床病程的差异为捕捉发育过程中临床特征变化的标准提供了进一步的支持。
Threshold and subthreshold forms of generalized anxiety disorder (GAD) are highly prevalent and impairing conditions among adults. However, there are few general population studies that have examined these conditions during the early life course. The primary objectives of this study were to: (1) examine the prevalence, and sociodemographic and clinical characteristics of threshold and subthreshold forms of GAD in a nationally representative sample of US youth; and (2) test differences in sociodemographic and clinical characteristics between threshold and subthreshold forms of the disorder. The National Comorbidity Survey-Adolescent Supplement is a nationally representative face-to-face survey of 10123 adolescents 13 to 18 years of age in the continental USA. Approximately 3% of adolescents met criteria for threshold GAD. Reducing the required duration from 6 months to 3 months resulted in a 65.7% increase in prevalence (5.0%); further relaxing the uncontrollability criterion led to an additional 20.7% increase in prevalence (6.1%). Adolescents with all forms of GAD displayed a recurrent clinical course marked by substantial impairment and co-morbidity with other psychiatric disorders. There were few significant differences in sociodemographic and clinical characteristics between threshold and subthreshold cases of GAD. Results also revealed age-related differences in the associated symptoms and clinical course of GAD. Findings demonstrate the clinical significance of subthreshold forms of GAD among adolescent youth, highlighting the continuous nature of the GAD construct. Age-related differences in the associated symptoms and clinical course of GAD provide further support for criteria that capture variation in clinical features across development.