Detecting immigration by using multilocus genotypes
Detecting immigration by using multilocus genotypes
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DOI：
10.1073/pnas.94.17.9197
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发表时间：
1997-08-19
影响因子：
11.1
通讯作者：
Mountain, JL
中科院分区：
文献类型：
--
作者：
Rannala, B;Mountain, JL
移民是塑造社会结构、进化和群体遗传的重要力量。提出了一种使用多位点基因型来识别移民或最近有移民血统的个体的统计方法，该方法适用于同工酶、微卫星或限制性片段长度多态性（RFLPs），并假设位点之间的连锁平衡。潜在的应用包括动物和植物自然种群之间的传播研究，人类进化研究，以及未知来源的动物园动物分型（用于圈养繁殖计划）。该方法通过分析来自澳大利亚，日本，新几内亚和塞内加尔种群的人类样本中的RFLP基因型来说明，该测试具有检测移民祖先的能力。在过去的两代中，尽管等位基因频率的总体分化在人群中很低。
Immigration is an important force shaping the social structure, evolution, and genetics of populations, A statistical method is presented that uses multilocus genotypes to identify individuals who are immigrants, or have recent immigrant ancestry, The method is appropriate for use with allozymes, microsatellites, or restriction fragment length polymorphisms (RFLPs) and assumes linkage equilibrium among loci, Potential applications include studies of dispersal among natural populations of animals and plants, human evolutionary studies, and typing zoo animals of unknown origin (for use in captive breeding programs), The method is illustrated by analyzing RFLP genotypes in samples of humans from Australian, Japanese, New Guinean, and Senegalese populations, The test has power to detect immigrant ancestors, for these data, up to two generations in the past even though the overall differentiation of allele frequencies among populations is low.