THE DESMOPLASTIC AND OSTEOPLASTIC AMELOBLASTOMA - HISTOLOGIC VARIANT OR CLINICOPATHOLOGICAL ENTITY - CASE-REPORTS
THE DESMOPLASTIC AND OSTEOPLASTIC AMELOBLASTOMA - HISTOLOGIC VARIANT OR CLINICOPATHOLOGICAL ENTITY - CASE-REPORTS
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DOI：
10.1016/s0901-5027(05)80761-1
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发表时间：
1992-12-01
影响因子：
2.4
通讯作者：
REICHART, PA
中科院分区：
文献类型：
--
作者：
PHILIPSEN, HP;ORMISTON, IW;REICHART, PA
两例促结缔组织增生性成釉细胞瘤（DA），使报告的病例总数为29。一个所谓的“混合病变”的情况下被添加到介绍。免疫组织化学研究表明，结缔组织增生是由细胞外基质蛋白的主动从头合成引起的。此外，DA也可能显示骨形成，这可能解释了许多DA的特征性X线表现，即同时出现放射线显影和不透射线改变，提示纤维骨病变。需要更多的DA病例来阐明这种最有趣的肿瘤的真实性质。
Two cases of desmoplastic ameloblastoma (DA) are presented, bringing the total number of reported cases to 29. One case of the so-called ''hybrid lesion'' is added to the presentation. Immunohistochemical studies indicate that the desmoplasia is caused by active de novo synthesis of extracellular matrix proteins. Moreover, the DA may also show osteoplasia, and this probably explains the characteristic radiographic appearance of many DAs, i.e. the occurrence of both radiolucent and radiopaque changes, suggestive of a fibro-osseous lesion. Many more cases of DA are needed to clarify the true nature of this most interesting tumor.