Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008.
Enterovirus co-infections and onychomadesis after hand, foot, and mouth disease, Spain, 2008.
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DOI：
10.3201/eid1712.110395
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发表时间：
2011-12
影响因子：
11.8
通讯作者：
Salazar A
中科院分区：
文献类型：
--
作者：
Bracho MA;González-Candelas F;Valero A;Córdoba J;Salazar A
肠道病毒的混合感染可能可以解释指甲脱落的罕见并发症。手足口病后的甲脱症 手足口病 (HFMD) 是一种由肠道病毒 (EV) 引起的常见疾病，通常影响儿童。 2008 年夏季和秋季，西班牙巴伦西亚发生了聚集性和散发性手足口病病例，随后出现脱甲症（指甲脱落）。来自曾患或未患过手足口病的甲脱症患者以及接触过甲脱症患者的健康儿童的粪便样本检测出 EV 呈阳性。获得完整的病毒蛋白1衣壳基因序列用于分型和系统发育分析。在发生甲病疫情的托儿所中，柯萨奇病毒 A10 和柯萨奇病毒 B1 (CVB1) 两种 EV 血清型主要以单一感染或合并感染的形式检出。根据我们的结果，以及在西班牙儿童保育中心另外两起当代甲脱症疫情中检测到的 CVB1，我们提出，导致手足口病的 EV 血清型与 CVB1 血清型的混合感染可以解释手足口病后甲脱症的出现，这是一种罕见的晚期并发症。
Mixed infection of enteroviruses may explain the rare complication of nail shedding. Onychomadesis after HFMD Hand, foot, and mouth disease (HFMD), a common disease caused by enteroviruses (EVs), usually affects children. Clustered and sporadic HFMD cases, followed by onychomadesis (nail shedding), occurred during summer and fall 2008 in Valencia, Spain. Fecal samples from onychomadesis patients, who did or did not have previous HFMD, and from healthy children exposed to onychomadesis patients tested positive for EV. The complete viral protein 1 capsid gene sequence was obtained for typing and phylogenetic analysis. Two EV serotypes, coxsackievirus A10 and coxsackievirus B1 (CVB1), were mainly detected as a monoinfection or co-infection in a childcare center where an onychomadesis outbreak occurred. On the basis of our results, and detection of CVB1 in 2 other contemporary onychomadesis outbreaks in childcare centers in Spain, we propose that mixed infection of an EV serotype that causes HFMD, plus the serotype CVB1, could explain the emergence after HFMD of onychomadesis, a rare and late complication.