Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats.
Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats.
复制标题
环氧氯丙烷对非近交系 Sprague-Dawley 大鼠的吸入致癌性。
DOI：
10.1093/jnci/65.4.751
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Albert,RE
中科院分区：
文献类型：
--
作者：
Laskin,S;Sellakumar,AR;Kuschner,M;Nelson,N;LaMendola,S;Rusch,GM;Katz,GV;Dulak,NC;Albert,RE
在非近交系雄性SD大鼠上进行了直接作用烷化剂环氧氯丙烷(ECH)的吸入暴露实验。单次接触ECH 6小时和14天的随访显示，致死浓度的中位数约为360ppm。进一步的吸入实验是在每周5天6小时的暴露下进行的。短期30次接触100ppm ECH的140只大鼠中有15只发生鼻腔恶性鳞状细胞癌，3只大鼠出现呼吸道乳头状瘤。在100只大鼠中，终生暴露于30ppm会导致1只鼻腔恶性鳞癌和1只鼻乳头状瘤。100只大鼠终生暴露在10ppm的剂量下，没有鼻腔或呼吸道肿瘤发生。100只空气处理大鼠和50只未处理大鼠作为对照。观察到ECH的剂量率效应，因为接触100ppm(3000ppm-天)30天会产生15种癌症，而终身暴露于30ppm(8700ppm-天)会产生1种癌症，而终身暴露于10ppm(2500ppm-天)则没有癌症。
Inhalation exposure experiments with the direct-acting alkylating agent epichlorohydrin (ECH) were done on noninbred male Sprague-Dawley rats. Single 6-hour exposure to ECH and follow-up for 14 days showed the median lethal concentration to be about 360 ppm. Further inhalation experiments were done with 6-hour exposures 5 days/week. A short-term 30-exposure regimen with 100 ppm ECH produced malignant squamous cell carcinomas of the nasal cavity in 15 of 140 rats and respiratory tract papillomas in 3 rats. Among 100 rats, lifetime exposure to 30 ppm yielded 1 malignant squamous carcinoma of the nasal cavity plus 1 nasal papilloma. No nasal or respiratory tract tumors were produced by lifetime exposure of 100 rats to 10 ppm. As controls, 100 air-treated and 50 untreated rats were used. A dose-rate effect was observed for ECH inasmuch as 30-day exposures to 100 ppm (3,000 ppm-days) produced 15 cancers in comparison to the 1 cancer from the lifetime exposures to 30 ppm (8,700 ppm-days) and no cancers from lifetime exposure to 10 ppm (2,500 ppm-days).