Deficit and nondeficit forms of schizophrenia: the concept.
Deficit and nondeficit forms of schizophrenia: the concept.
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DOI：
10.1176/ajp.145.5.578
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发表时间：
1988-05
期刊：
影响因子：
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通讯作者：
W. Carpenter;D. Heinrichs;A. Wagman
中科院分区：
文献类型：
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作者：
W. Carpenter;D. Heinrichs;A. Wagman
作者提供了区分精神分裂症主要的、持久的阴性症状（称为“缺陷症状”）与继发于其他因素的更短暂的阴性症状的基本原理。他们认为，前者更有可能为精神分裂症综合征的有意义的亚型提供基础，而后者更有可能对当前可用的治疗产生反应。他们描述了使用基于纵向观察的临床判断来识别精神分裂症患者的缺陷和非缺陷亚型的经验，并提出了定义缺陷综合征精神分裂症的标准。
The authors provide a rationale for distinguishing the primary, enduring negative symptoms of schizophrenia (termed "deficit symptoms") from the more transient negative symptoms secondary to other factors. They argue that the former are more likely to provide a basis for meaningful subtyping of the schizophrenic syndrome, while the latter are more likely to respond to currently available treatments. They describe their experience in using clinical judgment based on longitudinal observations to identify deficit and nondeficit subtypes of schizophrenic patients and propose criteria for defining schizophrenia with the deficit syndrome.