(18)F-Sodium Fluoride Uptake in Abdominal Aortic Aneurysms: The SoFIA(3) Study.
(18)F-Sodium Fluoride Uptake in Abdominal Aortic Aneurysms: The SoFIA(3) Study.
复制标题
DOI：
10.1016/j.jacc.2017.11.053
复制
发表时间：
2018-02-06
影响因子：
24
通讯作者：
Newby DE
中科院分区：
文献类型：
--
作者：
Forsythe RO;Dweck MR;McBride OMB;Vesey AT;Semple SI;Shah ASV;Adamson PD;Wallace WA;Kaczynski J;Ho W;van Beek EJR;Gray CD;Fletcher A;Lucatelli C;Marin A;Burns P;Tambyraja A;Chalmers RTA;Weir G;Mitchard N;Tavares A;Robson JMJ;Newby DE
Fluorine-18–sodium fluoride (18F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque. In patients with abdominal aortic aneurysm (AAA), the authors assessed whether 18F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes. In prospective case-control (n = 20 per group) and longitudinal cohort (n = 72) studies, patients with AAA (aortic diameter >40 mm) and control subjects (aortic diameter <30 mm) underwent abdominal ultrasound, 18F-NaF PET-CT, CT angiography, and calcium scoring. Clinical endpoints were aneurysm expansion and the composite of AAA repair or rupture. Fluorine-18-NaF uptake was increased in AAA compared with nonaneurysmal regions within the same aorta (p = 0.004) and aortas of control subjects (p = 0.023). Histology and micro-PET-CT demonstrated that 18F-NaF uptake localized to areas of aneurysm disease and active calcification. In 72 patients within the longitudinal cohort study (mean age 73 ± 7 years, 85% men, baseline aneurysm diameter 48.8 ± 7.7 mm), there were 19 aneurysm repairs (26.4%) and 3 ruptures (4.2%) after 510 ± 196 days. Aneurysms in the highest tertile of 18F-NaF uptake expanded 2.5× more rapidly than those in the lowest tertile (3.10 [interquartile range (IQR): 2.34 to 5.92 mm/year] vs. 1.24 [IQR: 0.52 to 2.92 mm/year]; p = 0.008) and were nearly 3× as likely to experience AAA repair or rupture (15.3% vs. 5.6%; log-rank p = 0.043). Fluorine-18-NaF PET-CT is a novel and promising approach to the identification of disease activity in patients with AAA and is an additive predictor of aneurysm growth and future clinical events. (Sodium Fluoride Imaging of Abdominal Aortic Aneurysms [SoFIA3]; NCT02229006; Magnetic Resonance Imaging [MRI] for Abdominal Aortic Aneurysms to Predict Rupture or Surgery: The MA3RS Trial; ISRCTN76413758)
登录
查看更多内容
影响因子：
168.9
作者：
Fayad, Zahi A.;Mani, Venkatesh;Woodward, Mark;Kallend, David;Abt, Markus;Burgess, Tracy;Fuster, Valentin;Ballantyne, Christie M.;Stein, Evan A.;Tardif, Jean-Claude;Rudd, James H. F.;Farkouh, Michael E.;Tawakol, Ahmed
通讯作者：
Tawakol, Ahmed
DOI：
10.1136/heartjnl-2015-308779
发表时间：
2016-06-01
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Forsythe RO;Newby DE;Robson JM
通讯作者：
Robson JM
影响因子：
9.3
作者：
Courtois, Audrey;Nusgens, Betty V.;Sakalihasan, Natzi
通讯作者：
Sakalihasan, Natzi
影响因子：
7.5
作者：
Nchimi, Alain;Cheramy-Bien, Jean-Paul;Sakalihasan, Natzi
通讯作者：
Sakalihasan, Natzi
DOI：
10.1016/j.jamcollsurg.2004.07.031
发表时间：
2004-11-01
影响因子：
5.2
作者：
Kurvers, H;Veith, FJ;Santiago, C
通讯作者：
Santiago, C