Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats
Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats
复制标题
吗啡降低前扣带皮层细胞外谷氨酸水平：自由活动大鼠的体内微透析研究
DOI：
10.1016/j.brainres.2005.01.072
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发表时间：
2005-04-08
期刊：
影响因子：
2.9
通讯作者：
Wu, MF
中科院分区：
文献类型：
--
作者：
Hao, Y;Yang, JY;Wu, MF
在本研究中，我们研究了吗啡对细胞外谷氨酸在前扣带皮层（ACC）在自由活动的大鼠在体内微透析耦合高效液相色谱和电化学检测水平的影响。结果表明，急性或慢性吗啡处理均可使ACC细胞外谷氨酸水平降低，纳洛酮可逆转慢性吗啡处理引起的谷氨酸水平降低。本研究首次提供了吗啡降低ACC细胞外谷氨酸水平的神经化学证据，表明ACC中的谷氨酸参与了吗啡的中枢作用。(c)2005 Elsevier B.V.保留所有权利。
In the present study, we investigated the effect of morphine on the extracellular levels of glutamate in the anterior cingulate cortex (ACC) in freely moving rats using in vivo microdialysis coupled to high performance liquid chromatography and electrochemical detection. The results showed that either acute or chronic morphine treatment decreased the extracellular levels of glutamate in the ACC. Naloxone could reverse the decrease induced by chronic morphine treatment. The present study provided the first neurochemical evidence that morphine decreased extracellular levels of glutamate in the ACC, suggesting that glutamate in ACC is involved in the central actions of morphine. (c) 2005 Elsevier B.V. All rights reserved.