UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
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DOI：
10.3390/cells10071604
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发表时间：
2021-06-26
期刊：
影响因子：
6
通讯作者：
Bazzaro M
中科院分区：
文献类型：
--
作者：
Clemente V;Hoshino A;Meints J;Shetty M;Starr T;Lee M;Bazzaro M
UNC-45A（蛋白质 unc-45 同源物 A）是一种细胞骨架相关蛋白，具有双重且非互斥的作用，既是肌动球蛋白系统的调节剂，也是微管 (MT) 不稳定蛋白，该蛋白在人类癌症中过度表达，包括对 MT 稳定药物紫杉醇耐药的卵巢癌患者。 UNC-45A 在小鼠上生殖道和中枢神经系统中的定位显示，其不仅在高度增殖和易于重塑的细胞中富集，而且在卵巢和神经系统的微管丰富区域中也分别富集。在这两种装置中，UNC-45A 在纤毛上皮中也大量表达。由于肌动球蛋白收缩性和 MT 稳定性的调节剂对于女性生殖道和神经元发育的病理生理学至关重要，因此我们的研究结果表明 UNC-45A 可能在卵巢癌的发生和发展以及神经变性中发挥作用。
UNC-45A (Protein unc-45 homolog A) is a cytoskeletal-associated protein with a dual and non-mutually exclusive role as a regulator of the actomyosin system and a Microtubule (MT)-destabilizing protein, which is overexpressed in human cancers including in ovarian cancer patients resistant to the MT-stabilizing drug paclitaxel. Mapping of UNC-45A in the mouse upper genital tract and central nervous system reveals its enrichment not only in highly proliferating and prone to remodeling cells, but also in microtubule-rich areas, of the ovaries and the nervous system, respectively. In both apparatuses, UNC-45A is also abundantly expressed in the ciliated epithelium. As regulators of actomyosin contractility and MT stability are essential for the physiopathology of the female reproductive tract and of neuronal development, our findings suggest that UNC-45A may have a role in ovarian cancer initiation and development as well as in neurodegeneration.
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