Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study
Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study
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DOI：
10.1016/j.jid.2017.07.822
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发表时间：
2017-12-01
影响因子：
6.5
通讯作者：
Saunes, Marit
中科院分区：
文献类型：
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作者：
Snekvik, Ingrid;Smith, Catherine H.;Saunes, Marit
尽管银屑病与肥胖有关，但很少有具有客观衡量标准的前瞻性研究。在挪威基于人群的Nord-Trondelag Health Study(即Hunt)中，我们前瞻性地研究了体重指数、腰围、腰臀比和10年体重变化对33,734人患银屑病风险的影响。在随访期间，共发生369例银屑病事件。用Cox回归估计银屑病的相对危险度(RR)。标准差越大，体重指数、腰围、腰臀比的相对危险度分别为1.22(95%可信区间=1.11~1.34)、1.26(95%CI=1.15=1.39)、1.18(95%CI=1.07~1.31)。与体重正常的受试者相比，肥胖者的相对危险度为1.87(95%CI=1.38-2.52)，而将腰围的第四个四分之一与腰围的第一个四分之一比较，相对危险度为1.95(95%CI=1.46-2.61)。体重变化1个标准差的相对危险度为1.20(95%CI=1.07-1.35)，体重增加10公斤或以上的人与体重稳定的人相比，相对危险度为1.72(95%CI=1.15-2.58)。总而言之，肥胖和腹部脂肪过多会使患牛皮癣的风险增加一倍，而长期的体重增加会显著增加患牛皮癣的风险。防止体重增加和促进保持正常体重可以降低牛皮癣的发病率。
Although psoriasis has been associated with obesity, there are few prospective studies with objective measures. We prospectively examined the effect of body mass index, waist circumference, waist-hip ratio, and 10-year weight change on the risk of developing psoriasis among 33,734 people in the population-based Nord-Trondelag Health Study (i.e., HUNT), Norway. During follow-up, 369 incident psoriasis cases occurred. Relative risk (RR) of psoriasis was estimated by Cox regression. One standard deviation higher body mass index, waist circumference, and waist-hip ratio gave RRs of 1.22 (95% confidence interval [CI] = 1.11-1.34), 1.26 (95% CI = 1.15=1.39), and 1.18 (95% CI = 1.07-1.31), respectively. Compared with normal weight participants, obese people had an RR of 1.87 (95% CI = 1.38-2.52), whereas comparing the fourth with the first quartile of waist circumference gave an RR of 1.95 (95% CI = 1.46-2.61). One standard deviation higher weight change gave an RR of 1.20 (95% CI = 1.07-1.35), and people who increased their body weight by 10 kg or more had an RR of 1.72 (95% CI = 1.15-2.58) compared with being weight stable. In conclusion, obesity and high abdominal fat mass doubles the risk of psoriasis, and long-term weight gain substantially increases psoriasis risk. Preventing weight gain and promoting maintenance of a normal body weight could reduce incidence of psoriasis.