Risk factors for dengue virus infection in rural Amazonia:: Population-based cross-sectional surveys
Risk factors for dengue virus infection in rural Amazonia:: Population-based cross-sectional surveys
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DOI：
10.4269/ajtmh.2008.79.485
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发表时间：
2008-10-01
影响因子：
3.3
通讯作者：
Ferreira, Marcelo U.
中科院分区：
文献类型：
--
作者：
da Silva-Nunes, Monica;de Souza, Vanda A. F.;Ferreira, Marcelo U.
在巴西亚马逊地区一个农业居民点收集的主要为登革热病毒（DENV）初发居民的配对血清样本（基线血清阳性率为18.3%）中，登革热病毒（DENV）抗体水平的比较显示，在12个月的随访期间，血清转化率为3.67次/100人年。多变量分析发现，男性性别、贫困和来自亚马逊以外地区的移民是基线DENY血清阳性的重要预测因素，而男性性别、登革热临床诊断史和前往城市地区的旅行预测随后的血清转化。2004年至2006年期间在研究地点和附近一个城镇对急性发热性疾病进行的实验室监测证实了11例。采用DENV IgM检测、逆转录聚合链反应和病毒分离对102例DENV感染进行了研究；分离DENV-3。由于登革热病毒暴露与移徙或旅行有关，在访问城市高危地区时采取个人防护措施可能会减少农村人口感染登革热病毒的发生率。
A comparison of dengue virus (DENV) antibody levels in paired serum samples collected from predominantly DENV-naive residents in an agricultural settlement in Brazilian Amazonia (baseline seroprevalence, 18.3%) showed a seroconversion rate of 3.67 episodes/100 person-years at risk during 12 months of follow-up. Multivariate analysis identified male sex, poverty, and migration from extra-Amazonian states as significant predictors of baseline DENY seropositivity, whereas male sex, a history of clinical diagnosis of dengue fever, and travel to an urban area predicted subsequent seroconversion. The laboratory surveillance of acute febrile illnesses implemented at the study site and in a nearby town between 2004 and 2006 confirmed 11. DENV infections among 102 episodes studied with DENV IgM detection, reverse transcriptase-polymerise chain reaction, and virus isolation; DENV-3 was isolated. Because DENV exposure is associated with migration or travel, personal protection measures when visiting high-risk urban areas may reduce the incidence of DENV infection in this rural population.