Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription
Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription
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DOI：
10.1016/s0896-6273(02)00737-7
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发表时间：
2002-06-13
期刊：
影响因子：
16.2
通讯作者：
Ghosh, A
中科院分区：
文献类型：
--
作者：
Redmond, L;Kashani, AH;Ghosh, A
We report that CaM kinase IV and CREB play a critical role in mediating calcium-induced dendritic growth in cortical neurons. Calcium-dependent dendritic growth is suppressed by CaM kinase inhibitors, a constitutively active form of CaM kinase IV induces dendritic growth in the absence of extracellular stimulation, and a kinase-dead form of CaM kinase IV suppresses dendritic growth induced by calcium influx. CaM kinase IV activates the transcription factor CREB, and expression of a dominant negative form of CREB blocks calcium- and CaM kinase IV-induced dendritic growth. In cortical slice cultures, dendritic growth is attenuated by inhibitors of voltage-sensitive calcium channels and by dominant negative CREB. These experiments indicate that calcium-induced dendritic growth is regulated by activation of a transcriptional program that involves CaM kinase IV and CREB-mediated signaling to the nucleus.
