Association of low plasma adiponectin with early diastolic dysfunction.
Association of low plasma adiponectin with early diastolic dysfunction.
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DOI：
10.1111/j.1751-7133.2011.00276.x
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发表时间：
2012-07-01
期刊：
影响因子：
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通讯作者：
Dudley, Samuel C Jr
中科院分区：
文献类型：
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作者：
Negi, Smita I;Jeong, Euy-Myoung;Dudley, Samuel C Jr
左心室射血分数（EF）正常的舒张功能障碍（DD）与肥胖有关。脂联素是一种与肥胖和肥胖相关的心血管并发症相关的细胞因子。作者旨在确定DD与脂联素的独立相关性。招募了50例舒张功能受损的DD和正常EF患者以及年龄匹配的正常对照。测定血浆总脂联素和高分子量（HMW）脂联素水平。通过从总脂联素中减去HMW部分来计算脂联素的中分子量和低分子量（MMW+LMW）部分。DD组的脂联素总量（中位数，4.4 vs 12.7 mug/mL; P= 0.001）、高分子量部分（中位数，1.3 vs 3.4 mug/mL; P= 0.02）和MMW+LMW部分（中位数，3.8 vs 7.2 mug/mL; P= 0.01）明显较低。体重指数（BMI）与脂联素的总（r：-0.46，P=.003）、HMW（r：-0.32，P=.038）和MMW+LMW（r：-0.40，P=.006）组分呈负相关。DD与BMI、BMI均独立相关（P
Diastolic dysfunction (DD) with preserved left ventricular (LV) ejection fraction (EF) has been linked to obesity. Adiponectin is a cytokine related to obesity and obesity-linked cardiovascular complications. The authors aimed to determine the independent association of DD with adiponectin. Fifty patients with impaired relaxation DD and a normal EF and age-matched normal controls were recruited. Plasma levels of total and high molecular weight (HMW) adiponectin were measured. Mid and low molecular weight (MMW+LMW) fractions of adiponectin were calculated by subtracting HMW fraction from total adiponectin. The DD group had significantly lower total (median, 4.4 vs 12.7 mug/mL; P=.001), HMW fraction (median, 1.3 vs 3.4 mug/mL; P=.02), and MMW+LMW fraction of adiponectin (median, 3.8 vs 7.2 mug/mL; P=.01). Body mass index (BMI) negatively correlated with total (r:-0.46, P=.003), HMW (r:-0.32, P=.038), and MMW+LMW (r:-0.40, P=.006) fractions of adiponectin. DD had an independent association with both BMI (P