Xanthan Gum and Its Derivatives as a Potential Bio-polymeric Carrier for Drug Delivery System
Xanthan Gum and Its Derivatives as a Potential Bio-polymeric Carrier for Drug Delivery System
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DOI：
10.2174/1567201811310050010
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发表时间：
2013-10-01
影响因子：
2.4
通讯作者：
Tripathi, Dulal Krishna
中科院分区：
文献类型：
--
作者：
Badwaik, Hemant R.;Giri, Tapan Kumar;Tripathi, Dulal Krishna
黄原胶是一种通过发酵工艺生产的高分子量天然多糖。它由1，4-连接的β-D-葡萄糖残基组成，具有连接到交替的D-葡萄糖基残基的三糖侧链。尽管胶具有许多药物递送所需的性质，但由于在生物流体中溶解缓慢和显著溶胀，其实际应用主要限于未改性的形式。黄原胶已通过常规化学方法如羧甲基化和接枝如自由基、微波辅助、化学酶和等离子体辅助化学接枝进行化学改性，以改变其物理化学性质，用于广泛的生物应用。本文综述了黄原胶的各种改性技术及其在药物释放系统中的应用。
Xanthan gum is a high molecular weight natural polysaccharide produced by fermentation process. It consists of 1, 4-linked beta-D-glucose residues, having a trisaccharide side chain attached to alternate D-glucosyl residues. Although the gum has many properties desirable for drug delivery, its practical use is mainly confined to the unmodified forms due to slow dissolution and substantial swelling in biological fluids. Xanthan gum has been chemically modified by conventional chemical methods like carboxymethylation, and grafting such as free radical, microwave-assisted, chemoenzymatic and plasma assisted chemical grafting to alter physicochemical properties for a wide spectrum of biological applications. This article reviews various techniques utilized for modification of xanthan gum and its applications in a range of drug delivery systems.