Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning
Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning
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DOI：
10.1016/s0925-4773(96)00609-0
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发表时间：
1996-12-01
影响因子：
2.6
通讯作者：
Edlund, H
中科院分区：
文献类型：
--
作者：
Larsson, LI;Madsen, OD;Edlund, H
胃肠道被细分成不同的区域，在消化和吸收中起着不同的作用。这种模式是如何建立的尚不清楚。我们现在报道胰腺-十二指肠同源盒1基因（pdx1）也在远端胃细胞中表达。阳性细胞包括该区域三种主要内分泌（胃泌素、生长抑素和血清素）细胞类型的亚群。Pdx1缺陷小鼠几乎没有胃泌素细胞，生长抑素细胞数量正常，血清素细胞数量增加。因此，Pdx1对于胃幽门黏膜胃泌素细胞的发育很重要，并可能通过控制胃泌素/血清素前体细胞的命运起作用。
The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene (pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three main endocrine (gastrin, somatostatin and serotonin) cell types of this region. Pdx1 deficient mice were virtually devoid of gastrin cells, had normal numbers of somatostatin cells and increased numbers of serotonin cells. Pdx1 is thus important for development of the gastrin cells of the antropyloric mucosa of the stomach and probably acts by controlling the fate of gastrin/serotonin precursor cells.