The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines
The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines
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DOI：
10.1016/s0306-4530(98)00087-0
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发表时间：
1999-05-01
影响因子：
3.7
通讯作者：
Neels, H
中科院分区：
文献类型：
--
作者：
Maes, M;Libbrecht, I;Neels, H
纤维肌痛是一种慢性、疼痛的肌肉骨骼疾病，其特征是广泛性疼痛、压力性痛觉过敏、晨僵以及抑郁症状发生率增加。然而，病因仍然难以捉摸。本研究旨在探讨纤维肌痛的炎症反应系统(IRS)。对33例健康志愿者和21例纤维肌痛患者的血清白介素6(IL-6)、可溶性白介素6受体(sIL-6R)、sgp130、sIL-1R拮抗剂(IL-IRA)和sCD8进行了检测。用多种疼痛评分、测痛法和汉密尔顿抑郁量表(HDRS)评估病情严重程度。纤维肌痛患者血清sgp130显著高于正常对照组，sCD8显著低于正常对照组。HDRS评分升高(大于或等于6)的纤维肌痛患者血清sIL-6R和sIL-IRA水平显著高于正常对照组和HDRS评分<16分的纤维肌痛患者。在纤维肌痛患者中，HDRS评分可解释sCD8(50.3%)和IL-1RA(19.3%)的重要变化，74.3%的sIL-6R变化可由疼痛症状和HDRS评分的综合作用解释，25.9%的血清sgp130变化可用僵硬来解释。这些结果支持这样的观点，即纤维肌痛的疼痛和僵硬可能伴随着IRS的某些方面的抑制，并且纤维肌痛临床上明显的抑郁症状的出现与IRS激活的一些迹象有关。(C)1999爱思唯尔科学有限公司。保留所有权利。
Fibromyalgia is a chronic, painful musculoskeletal disorder characterized by widespread pain, pressure hyperalgesia, morning stiffness and by an increased incidence of depressive symptoms. The etiology, however, has remained elusive. The aim of the present study was to examine the inflammatory response system (IRS) in fibromyalgia. Serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), sgp130, sIL-1R antagonist (IL-IRA) and sCD8 were determined in 33 healthy volunteers and in 21 fibromyalgia patients, classified according to the American College of Rheumatology criteria. Severity of illness was measured with several pain scales, dolorimetry and the Hamilton Depression Rating Scale (HDRS). Serum sgp130 was significantly higher and serum sCD8 significantly lower in fibromyalgia patients than in healthy volunteers. Serum sIL-6R and sIL-IRA were significantly higher in fibromyalgia patients with an increased HDRS score (greater than or equal to 6) than in normal volunteers and fibromyalgia patients with a HDRS score < 16. In fibromyalgia patients, an important part of the variance in sCD8 (50.3%) and IL-1RA (19.3%) could be explained by the HDRS score; 74.3% of the variance in sIL-6R was explained by the combined effects of pain symptoms and the HDRS score; and 25.9% of the variance in serum sgp130 was explained by stiffness. The results support the contention that pain and stiffness in fibromyalgia may be accompanied by a suppression of some aspects of the IRS and that the presence of clinically significant depressive symptoms in fibromyalgia is associated with some signs of IRS activation. (C) 1999 Elsevier Science Ltd. All rights reserved.