Smoking and risk of coronary heart disease among women with type 2 diabetes mellitus
Smoking and risk of coronary heart disease among women with type 2 diabetes mellitus
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DOI：
10.1001/archinte.162.3.273
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发表时间：
2002-02-11
影响因子：
--
通讯作者：
Hu, FB
中科院分区：
文献类型：
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作者：
Al-Delaimy, WK;Manson, JE;Hu, FB
背景资料：虽然吸烟与冠心病（CHD）风险增加之间的关系在普通人群中已得到很好的证实，但在糖尿病患者中这种关系尚不明确。目的：评估护士健康研究队列中女性2型糖尿病患者吸烟与CHD风险之间的关系。护士健康研究是一项前瞻性队列研究，调查了11个州的121700名美国女性注册护士，并从1976年7月1日至1996年7月1日进行随访，共涉及6547名诊断为2型糖尿病的女性。冠心病事件的情况下，我们的主要成果measurementin this study.Results：我们记录了458例冠心病事件（200例致命的冠心病相关病例和258例非致命性心肌梗死）在20年（68227人年）的后续行动。我们发现糖尿病女性中吸烟状况与冠心病风险之间存在剂量反应关系。与从不吸烟者相比，冠心病的相对危险度（RR）为1.21（95%置信区间[CI]，0.97-1.51）既往吸烟者，1.66（95% CI，1.10-2.52），目前每天吸烟1 - 14支，2.68在多变量分析中，目前每天吸烟15支或以上的吸烟者（95%CI，2.07-3.48）（P
Background: Although the association between smoking and increased risk of coronary heart disease (CHD) is well established in the general population, this relationship is less well-defined among individuals with diabetes.Objective: To assess the relationship between cigarette smoking and risk of CHD among women with type 2 diabetes mellitus in the Nurses' Health Study cohort.Methods: The Nurses' Health Study, a prospective cohort study of 121700 US female registered nurses surveyed in 11 states and followed up from July 1, 1976, through July 1, 1996, involved a total of 6547 women diagnosed as having type 2 diabetes mellitus. Incident cases of CHD were our main outcome measure in this study.Results: We documented 458 incident cases of CHD (200 fatal CHD-related cases and 258 nonfatal myocardial infarctions) during 20 years (68227 person-years) of follow-up. We found a dose-response relationship between current smoking status and risk of CHD among diabetic women. Compared with never smokers, the relative risks (RRs) for CHD were 1.21 (95% confidence interval [CI], 0.97-1.51) for past smokers, 1.66 (95% CI, 1.10-2.52) for current smokers of 1 to 14 cigarettes per day, and 2.68 (95% CI, 2.07-3.48) for current smokers of 15 or more cigarettes per day in multivariate analyses (P