High-frequency color flow imaging of the microcirculation
High-frequency color flow imaging of the microcirculation
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DOI：
10.1016/s0301-5629(99)00101-5
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发表时间：
2000-01-01
影响因子：
2.9
通讯作者：
Foster, FS
中科院分区：
文献类型：
--
作者：
Goertz, DE;Christopher, DA;Foster, FS
超声（US）彩色血流成像（CFI）技术向高频（bbb20 MHz）的扩展，有可能为微循环中的血液下降的科学和临床研究提供有价值的非侵入性工具。我们描述了在20-100 mhz范围内工作的慢扫描CFI系统的开发，该系统已被优化为微循环成像，该设备包含了先前报道的脉冲波多普勒系统的元素，能够在CFI或脉冲波模式下工作。CFI系统的性能在中心频率为50 MHz时进行了评估，使用两个PVDF换能器，- 6db波束宽度分别为43和60 μ m，估计- 6db轴向分辨率分别为66和72 μ m。使用小鼠耳模型进行的体内验证实验表明，可以检测到直径为15-20 μ m的血管中的血流，其速度约为mm / s。进一步检查实验性小鼠肿瘤的实验证实了在肿瘤微循环中成功检测到dow， (C) 2000年世界超声医学与生物学联合会。
The extension of ultrasound (US) color flow imaging (CFI) techniques to high frequencies ( > 20 MHz) has the potential to provide valuable noninvasive tools for scientific and clinical investigations of blood dow in the microcirculation. We describe the development of a slow-scan CFI system operating in the 20-100-MHz range that has been optimized to image the microcirculation, The apparatus has incorporated elements of a previously reported pulsed-wave Doppler system and is capable of operating in either CFI or pulsed-wave mode. The performance of the CFI system was evaluated at a center frequency of 50 MHz using two PVDF transducers with -6-dB beam widths of 43 and 60 mu m. The -6 dB-axial resolutions were estimated to be 66 and 72 mu m, respectively. In vivo validation experiments conducted using the murine ear model demonstrated the detection of flow in vessels down to 15-20 mu m in diameter with how velocities on the order of mm per s, Further experiments examining experimental murine tumors confirmed the successful detection of dow in the tumor microcirculation, (C) 2000 World Federation for Ultrasound in Medicine & Biology.