Bioelectrical impedance analysis of the body composition of children and adolescents with sickle cell disease.
Bioelectrical impedance analysis of the body composition of children and adolescents with sickle cell disease.
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镰状细胞病儿童和青少年身体成分的生物电阻抗分析。
DOI：
10.1067/mpd.2002.124385
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Glew,RobertH
中科院分区：
文献类型：
--
作者：
VanderJagt,DorothyJ;Harmatz,Paul;Scott-Emuakpor,AjoviB;Vichinsky,Elliot;Glew,RobertH
目的：检查身体组成的儿童和青少年与镰状细胞病（SCD）使用生物电阻抗分析，并确定阻抗参数电阻，电抗，和相位角是否能够区分与SCD和年龄和性别匹配的controls.Study design：总身体电阻和电抗获得了共53名受试者与SCD（27名男性和26名女性）之间的10和18岁和49名对照组受试者（23名男性和26名女性）。还测定了去脂质量、体细胞质量、相位角和电容。结果：与对照组相比，男性SCD患者的去脂体重（37.5 ± 8.8 vs 43.9 ± 12.3 kg，P = 0.04）、体细胞质量（17.4 ± 4.3 vs 21.7 ± 5.8 kg，P = 0.005）和体脂（3.7 ± 2.6 vs 6.6 ± 4.7 kg，P = 0.008）显著降低。女性受试者的任何身体组成成分均无显著差异。男性和女性受试者有显着降低相位角测量（P <0.001和0.006，分别）比各自的控制，表明可能的改变，因为在膜组成或功能的不平衡，细胞膜的特性。结论：生物电阻抗分析可以用来确定身体组成的差异，在儿童SCD。相位角可以提供一种有用的方法来监测SCD患者的治疗干预的疗效。（J Pediatr 2002; 140：681 - 7）
Objectives:To examine the body composition of children and adolescents with sickle cell disease (SCD) using bioelectrical impedance analysis and to determine if the impedance parameters resistance, reactance, and phase angle are able to distinguish between subjects with SCD and age- and gender matched controls.Study design:Total body resistance and reactance were obtained for a total of 53 subjects with SCD (27 male and 26 female) between 10 and 18 years of age and 49 control subjects (23 male and 26 female). The fat-free mass, body cell mass, phase angle, and capacitance were also determined. Group comparisons were made using the 2-samplettest.Results:Male subjects with SCD had significantly lower fat-free mass (37.5 ± 8.8 vs 43.9 ± 12.3 kg,P=.04), body cell mass (17.4 ± 4.3 vs 21.7 ± 5.8 kg,P=.005), and body fat (3.7 ± 2.6 vs 6.6 ± 4.7 kg,P=.008) compared with controls. No significant differences in any body composition components were found for the female subjects. Both male and female subjects had significantly lower phase angle measurements (P<.001 and.006, respectively) than their respective controls, indicating possible alterations in cell membrane properties because of an imbalance in membrane composition or function.Conclusions:Bioelectrical impedance analysis can be used to determine body composition differences in children with SCD. The phase angle may provide a useful method to monitor the efficacy of therapeutic interventions in patients with SCD. (J Pediatr 2002;140:681-7)