A new polyether ladder compound produced by the dinoflagellate Karenia brevis
A new polyether ladder compound produced by the dinoflagellate Karenia brevis
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DOI：
10.1021/np049797o
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发表时间：
2005-01-01
影响因子：
5.1
通讯作者：
Baden, DG
中科院分区：
文献类型：
--
作者：
Bourdelais, AJ;Jacocks, HM;Baden, DG
从海洋甲藻Karenia brevis的实验室培养物中分离得到一种含有5个稠环的新型梯形骨架聚醚化合物。这种名为Brivenal的化合物及其二甲缩醛衍生物都竞争性地将Brevetoxin从其在大鼠脑突触体中的结合位置置换出来。值得注意的是，这些化合物对鱼类也是无毒的，并能拮抗短杆菌毒素对鱼类的毒性作用。本文介绍了丁香醛及其二甲缩醛衍生物的结构和生物活性。
A new ladder-frame polyether compound containing five fused ether rings was isolated from laboratory cultures of the marine dinoflagellate Karenia brevis. This compound, named brevenal, and its dimethyl acetal derivative both competitively displace brevetoxin from its binding site in rat brain synaptosomes. Significantly, these compounds are also nontoxic to fish and antagonize the toxic effects of brevetoxins in fish. The structure and biological activity of brevenal, as well as the dimethyl acetal derivative, are described in this paper.