CTLA-4 upregulation during aging
CTLA-4 upregulation during aging
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DOI：
10.1016/s0047-6374(02)00077-5
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发表时间：
2002-07-01
影响因子：
5.3
通讯作者：
Borkow, G
中科院分区：
文献类型：
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作者：
Leng, QB;Bentwich, Z;Borkow, G
随着年龄的增长，免疫系统会逐渐失去活力。在这里，我们测量了53名年龄在18-94岁的健康个体的细胞内细胞毒性t淋巴细胞相关抗原4 （CTLA-4）的水平，CTLA-4是t细胞的负调节因子。我们发现年龄与CTLA-4+CD4+细胞百分比之间存在高度显著的相关性(r = 0。6, P < 0.001)，年龄与CTLA-4平均荧光强度（即分子数，r = 0.61, P < 0.001）之间的关系。CTLA-4水平也与免疫激活相关，由HLA-DR + CD3 +细胞水平决定（r = 0.55, P < 0.001）。我们假设，与年龄相关的免疫衰老部分是由慢性免疫激活引起的，与CD28共刺激分子减少和抑制性CTLA-4分子增加相关。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
The immune system gradually becomes anergic with age. Here, we measured intracellular levels of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), a negative regulator of T-cells, in 53 healthy individuals aged 18-94. We found a highly significant correlation between age and percent of CTLA-4+CD4+cells (r = 0. 6, P < 0.001) and between age and mean fluorescence intensities of CTLA-4 (i.e. number of molecules, r = 0.61, P < 0.001). CTLA-4 levels were also correlated with immune activation, determined by levels of HLA-DR + CD3 + cells (r = 0.55, P < 0.001). We postulate that immune senescence associated with age is caused in part by chronic immune activation with related decrease in CD28 costimulatory molecules and increase in inhibitory CTLA-4 molecules. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.