Inhibition of Lassa and Marburg Virus Production by Tetherin
Inhibition of Lassa and Marburg Virus Production by Tetherin
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DOI：
10.1128/jvi.01607-08
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发表时间：
2009-03-01
影响因子：
5.4
通讯作者：
Yasuda, Jiro
中科院分区：
文献类型：
--
作者：
Sakuma, Toshie;Noda, Takeshi;Yasuda, Jiro
最近，栓系蛋白已被确定为一种有效的细胞因子，可防止人类免疫缺陷病毒1型的释放。在这里，我们表明，拉沙病毒或马尔堡病毒的病毒基质蛋白诱导的病毒样颗粒的生产被显着抑制的系链蛋白和N-连接的糖基化的系链蛋白被证明这种抗病毒活性。我们的数据还表明，病毒基质蛋白或一个或多个组件，来源于宿主细胞是tetherin的目标，但病毒表面糖蛋白不是。这些结果表明，系链蛋白通过共同的机制抑制多种包膜病毒从宿主细胞中释放。
Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation of tetherin was dispensable for this antiviral activity. Our data also suggest that viral matrix proteins or one or more components that originate from host cells are targets of tetherin but that viral surface glycoproteins are not. These results suggest that tetherin inhibits the release of a wide variety of enveloped viruses from host cells by a common mechanism.